Detailed information NTG0487849

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF760_RS00455
• Genome accession: NZ_CP062331
• Coordinates: 81980..83023 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_OP_017
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76980..88023

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF760_RS00425 (IF760_00430)	-	77409..77519 (+)	111	WP_001790257.1	hypothetical protein	-
IF760_RS00430 (IF760_00435)	-	77548..77961 (+)	414	WP_001549145.1	hypothetical protein	-
IF760_RS00435 (IF760_00440)	-	78392..79378 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
IF760_RS00440 (IF760_00445)	map	79906..80664 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF760_RS00445 (IF760_00450)	-	80881..81267 (+)	387	WP_001110179.1	hypothetical protein	-
IF760_RS00450 (IF760_00455)	liaF	81282..81983 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF760_RS00455 (IF760_00460)	vraS	81980..83023 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF760_RS00460 (IF760_00465)	vraR	83013..83642 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
IF760_RS00465 (IF760_00470)	-	83758..84975 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
IF760_RS00470 (IF760_00475)	-	85253..85528 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF760_RS00475 (IF760_00480)	-	85535..85999 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF760_RS00480 (IF760_00485)	-	86146..86346 (+)	201	WP_000180461.1	DUF1128 family protein	-
IF760_RS00485 (IF760_00490)	-	86349..87605 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=487849 IF760_RS00455 WP_001017131.1 81980..83023(+) (vraS) [Staphylococcus aureus strain NAS_OP_017]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=487849 IF760_RS00455 WP_001017131.1 81980..83023(+) (vraS) [Staphylococcus aureus strain NAS_OP_017]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1