Detailed information NTG0487559

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF776_RS00455
• Genome accession: NZ_CP062314
• Coordinates: 82039..83082 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_OP_133
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77039..88082

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF776_RS00425 (IF776_00430)	-	77409..77519 (+)	111	WP_001790257.1	hypothetical protein	-
IF776_RS00430 (IF776_00435)	-	77548..77961 (+)	414	WP_001549145.1	hypothetical protein	-
IF776_RS00435 (IF776_00440)	-	78451..79437 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
IF776_RS00440 (IF776_00445)	map	79965..80723 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF776_RS00445 (IF776_00450)	-	80940..81326 (+)	387	WP_001110179.1	hypothetical protein	-
IF776_RS00450 (IF776_00455)	liaF	81341..82042 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF776_RS00455 (IF776_00460)	vraS	82039..83082 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF776_RS00460 (IF776_00465)	vraR	83072..83701 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
IF776_RS00465 (IF776_00470)	-	83817..85034 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
IF776_RS00470 (IF776_00475)	-	85312..85587 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF776_RS00475 (IF776_00480)	-	85594..86058 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF776_RS00480 (IF776_00485)	-	86205..86405 (+)	201	WP_000180461.1	DUF1128 family protein	-
IF776_RS00485 (IF776_00490)	-	86408..87664 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=487559 IF776_RS00455 WP_001017131.1 82039..83082(+) (vraS) [Staphylococcus aureus strain NAS_OP_133]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=487559 IF776_RS00455 WP_001017131.1 82039..83082(+) (vraS) [Staphylococcus aureus strain NAS_OP_133]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1