Detailed information NTG0487518

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF782_RS00455
• Genome accession: NZ_CP062312
• Coordinates: 81971..83014 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_OP_163
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76971..88014

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF782_RS00425 (IF782_00425)	-	77456..77566 (+)	111	WP_001790257.1	hypothetical protein	-
IF782_RS00430 (IF782_00430)	-	77595..78008 (+)	414	WP_001566709.1	hypothetical protein	-
IF782_RS00435 (IF782_00435)	-	78439..79425 (-)	987	WP_000999720.1	aromatic acid exporter family protein	-
IF782_RS00440 (IF782_00440)	map	79897..80655 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF782_RS00445 (IF782_00445)	-	80872..81258 (+)	387	WP_001110179.1	hypothetical protein	-
IF782_RS00450 (IF782_00450)	liaF	81273..81974 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF782_RS00455 (IF782_00455)	vraS	81971..83014 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF782_RS00460 (IF782_00460)	vraR	83004..83633 (+)	630	WP_000153531.1	two-component system response regulator VraR	Regulator
IF782_RS00465 (IF782_00465)	-	83745..84962 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
IF782_RS00470 (IF782_00470)	-	85240..85515 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF782_RS00475 (IF782_00475)	-	85522..85986 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF782_RS00480 (IF782_00480)	-	86133..86333 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF782_RS00485 (IF782_00485)	-	86336..87592 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=487518 IF782_RS00455 WP_001017131.1 81971..83014(+) (vraS) [Staphylococcus aureus strain NAS_OP_163]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=487518 IF782_RS00455 WP_001017131.1 81971..83014(+) (vraS) [Staphylococcus aureus strain NAS_OP_163]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1