Detailed information NTG0481423

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: D39N_RS08845
• Genome accession: NZ_CP061208
• Coordinates: 1764462..1765499 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain D39_P0
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1759462..1770499

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D39N_RS08820 (D39N_01771)	-	1760263..1761594 (-)	1332	WP_000390046.1	hemolysin family protein	-
D39N_RS08825 (D39N_01772)	endA	1761823..1762647 (-)	825	WP_001036779.1	DNA-entry nuclease EndA	Machinery gene
D39N_RS08830 (D39N_01773)	-	1762686..1762874 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
D39N_RS08835 (D39N_01774)	murA	1762867..1764150 (-)	1284	WP_000358027.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
D39N_RS08840 (D39N_01775)	-	1764174..1764404 (-)	231	WP_000250384.1	DUF1146 family protein	-
D39N_RS08845 (D39N_01776)	sepM	1764462..1765499 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
D39N_RS08850 (D39N_01777)	coaD	1765483..1765971 (-)	489	WP_001280727.1	pantetheine-phosphate adenylyltransferase	-
D39N_RS08855 (D39N_01778)	rsmD	1765961..1766500 (-)	540	WP_000706962.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
D39N_RS08860 (D39N_01779)	asnA	1766565..1767557 (-)	993	WP_000747995.1	aspartate--ammonia ligase	-
D39N_RS08865 (D39N_01780)	-	1767669..1768352 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
D39N_RS08870 (D39N_01781)	-	1768408..1769148 (-)	741	WP_000152673.1	RNA methyltransferase	-
D39N_RS08875 (D39N_01782)	-	1769182..1769460 (+)	279	WP_001174613.1	acylphosphatase	-
D39N_RS08880 (D39N_01783)	yidC	1769538..1770464 (+)	927	WP_000835947.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=481423 D39N_RS08845 WP_000727277.1 1764462..1765499(-) (sepM) [Streptococcus pneumoniae strain D39_P0]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=481423 D39N_RS08845 WP_000727277.1 1764462..1765499(-) (sepM) [Streptococcus pneumoniae strain D39_P0]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGCATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591