Detailed information NTG0480994

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: IB935_RS06220
• Genome accession: NZ_CP061134
• Coordinates: 1240864..1241901 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain BSAC_bs192 isolate Invasive disease
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1235864..1246901

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IB935_RS06200 (IB935_06200)	-	1236613..1237240 (+)	628	Protein_1181	prepilin peptidase	-
IB935_RS06205 (IB935_06205)	rlmN	1237322..1238401 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
IB935_RS06210 (IB935_06210)	-	1238405..1239025 (-)	621	WP_002992791.1	YutD family protein	-
IB935_RS06215 (IB935_06215)	-	1239473..1240450 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
IB935_RS06220 (IB935_06220)	sepM	1240864..1241901 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
IB935_RS06225 (IB935_06225)	coaD	1241888..1242379 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
IB935_RS06230 (IB935_06230)	rsmD	1242369..1242908 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
IB935_RS06235 (IB935_06235)	asnA	1243031..1244023 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
IB935_RS06240 (IB935_06240)	arcC	1244336..1245286 (-)	951	WP_011528820.1	carbamate kinase	-
IB935_RS06245 (IB935_06245)	-	1245306..1246637 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=480994 IB935_RS06220 WP_002983824.1 1240864..1241901(-) (sepM) [Streptococcus pyogenes strain BSAC_bs192 isolate Invasive disease]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=480994 IB935_RS06220 WP_002983824.1 1240864..1241901(-) (sepM) [Streptococcus pyogenes strain BSAC_bs192 isolate Invasive disease]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69