Detailed information NTG0480869

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: IB937_RS02930
• Genome accession: NZ_CP061132
• Coordinates: 580662..581699 (+)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain BSAC_bs1388 isolate Invasive disease
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 575662..586699

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IB937_RS02905 (IB937_02905)	-	575926..577257 (+)	1332	WP_011054719.1	dipeptidase	-
IB937_RS02910 (IB937_02910)	arcC	577277..578227 (+)	951	WP_011528820.1	carbamate kinase	-
IB937_RS02915 (IB937_02915)	asnA	578540..579532 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
IB937_RS02920 (IB937_02920)	rsmD	579655..580194 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
IB937_RS02925 (IB937_02925)	coaD	580184..580675 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
IB937_RS02930 (IB937_02930)	sepM	580662..581699 (+)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
IB937_RS02935 (IB937_02935)	-	582113..583090 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
IB937_RS02940 (IB937_02940)	-	583538..584158 (+)	621	WP_002992791.1	YutD family protein	-
IB937_RS02945 (IB937_02945)	rlmN	584162..585241 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
IB937_RS02950 (IB937_02950)	-	585323..585950 (-)	628	Protein_520	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=480869 IB937_RS02930 WP_002983824.1 580662..581699(+) (sepM) [Streptococcus pyogenes strain BSAC_bs1388 isolate Invasive disease]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=480869 IB937_RS02930 WP_002983824.1 580662..581699(+) (sepM) [Streptococcus pyogenes strain BSAC_bs1388 isolate Invasive disease]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69