Detailed information NTG0480827

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: IB938_RS06805
• Genome accession: NZ_CP061131
• Coordinates: 1319606..1320643 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain BSAC_bs1802 isolate Invasive disease
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1314606..1325643

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IB938_RS06785 (IB938_06785)	-	1315355..1315982 (+)	628	Protein_1303	prepilin peptidase	-
IB938_RS06790 (IB938_06790)	rlmN	1316064..1317143 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
IB938_RS06795 (IB938_06795)	-	1317147..1317767 (-)	621	WP_002992791.1	YutD family protein	-
IB938_RS06800 (IB938_06800)	-	1318215..1319192 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
IB938_RS06805 (IB938_06805)	sepM	1319606..1320643 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
IB938_RS06810 (IB938_06810)	coaD	1320630..1321121 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
IB938_RS06815 (IB938_06815)	rsmD	1321111..1321650 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
IB938_RS06820 (IB938_06820)	asnA	1321773..1322765 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
IB938_RS06825 (IB938_06825)	arcC	1323078..1324028 (-)	951	WP_011528820.1	carbamate kinase	-
IB938_RS06830 (IB938_06830)	-	1324048..1325379 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=480827 IB938_RS06805 WP_002983824.1 1319606..1320643(-) (sepM) [Streptococcus pyogenes strain BSAC_bs1802 isolate Invasive disease]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=480827 IB938_RS06805 WP_002983824.1 1319606..1320643(-) (sepM) [Streptococcus pyogenes strain BSAC_bs1802 isolate Invasive disease]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69