Detailed information NTG0048012

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: SPN994038_RS00485
• Genome accession: NC_021026
• Coordinates: 74457..76610 (+)
• Length: 717 a.a.
• NCBI ID: WP_000668304.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae SPN994038
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 69457..81610

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPN994038_RS00450 (SPN994038_00800)	-	69808..70977 (+)	1170	WP_000366345.1	pyridoxal phosphate-dependent aminotransferase	-
SPN994038_RS00455 (SPN994038_00810)	recO	70974..71744 (+)	771	WP_000616162.1	DNA repair protein RecO	Machinery gene
SPN994038_RS00460 (SPN994038_00820)	plsX	71741..72733 (+)	993	WP_000717457.1	phosphate acyltransferase PlsX	-
SPN994038_RS00465 (SPN994038_00830)	-	72739..72972 (+)	234	WP_000659556.1	acyl carrier protein	-
SPN994038_RS11000 (SPN994038_00840)	-	73009..73309 (+)	301	Protein_84	transposase family protein	-
SPN994038_RS00470 (SPN994038_00850)	blpU	73512..73742 (+)	231	Protein_85	bacteriocin-like peptide BlpU	-
SPN994038_RS13150 (SPN994038_00860)	-	73745..73870 (+)	126	WP_000346297.1	PncF family bacteriocin immunity protein	-
SPN994038_RS00485 (SPN994038_00870)	comA	74457..76610 (+)	2154	WP_000668304.1	peptide cleavage/export ABC transporter ComA	Regulator
SPN994038_RS00490 (SPN994038_00880)	comB	76623..77972 (+)	1350	WP_000801618.1	competence pheromone export protein ComB	Regulator
SPN994038_RS00495 (SPN994038_00890)	purC	78142..78849 (+)	708	WP_000043304.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
SPN994038_RS13290	-	78851..78994 (+)	144	WP_050167432.1	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80436.52 Da
• Isoelectric Point: 6.2593

>NTDB_id=48012 SPN994038_RS00485 WP_000668304.1 74457..76610(+) (comA) [Streptococcus pneumoniae SPN994038]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPYKEQKNGLLSFIPI
LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELVEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=48012 SPN994038_RS00485 WP_000668304.1 74457..76610(+) (comA) [Streptococcus pneumoniae SPN994038]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCCGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTATAAGCCTTATAAGGAACAAAAAAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCGTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTAGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTTTTCGCGACACGCAGGACAGGGGAAATTGTGTC
TCGTTTCACGGATGCTAACAGTATTATCGATGCGCTGGCTTCGACCATTCTTTCGATTTTCCTAGATGTGTCAACAGTTG
TCATTATTTCCCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGACACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTACTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGAGATGACTTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTACGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGTAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTT
GGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTGGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterProScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter transmembrane region (ABC_membrane) (170-438)

• ABC transporter (ABC_tran) (500-650)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus pneumoniae Rx1	99.442	100	0.994
comA	Streptococcus pneumoniae D39	99.442	100	0.994
comA	Streptococcus pneumoniae R6	99.442	100	0.994
comA	Streptococcus pneumoniae TIGR4	99.024	100	0.99
comA	Streptococcus mitis SK321	98.466	100	0.985
comA	Streptococcus mitis NCTC 12261	98.187	100	0.982
comA	Streptococcus gordonii str. Challis substr. CH1	80.474	100	0.805
comA/nlmT	Streptococcus mutans UA159	64.435	100	0.644