Detailed information
Bioinformatically predicted
Overview
| Name | sepM | Type | Regulator |
| Locus tag | IBC03_RS07980 | Genome accession | NZ_CP061025 |
| Coordinates | 1545524..1546600 (-) | Length | 358 a.a. |
| NCBI ID | WP_011681549.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus strain 13496 | ||
| Function | processing of CSP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1530780..1603585 | 1545524..1546600 | within | 0 |
Gene organization within MGE regions
Location: 1530780..1603585
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IBC03_RS07905 (IBC03_07925) | - | 1531671..1532222 (-) | 552 | WP_002946999.1 | isochorismatase family cysteine hydrolase | - |
| IBC03_RS07910 (IBC03_07930) | codY | 1532285..1533070 (-) | 786 | WP_002951720.1 | GTP-sensing pleiotropic transcriptional regulator CodY | - |
| IBC03_RS07915 (IBC03_07935) | - | 1533330..1534544 (-) | 1215 | WP_002951721.1 | pyridoxal phosphate-dependent aminotransferase | - |
| IBC03_RS07920 (IBC03_07940) | - | 1534899..1535351 (+) | 453 | WP_002946987.1 | universal stress protein | - |
| IBC03_RS07925 (IBC03_07945) | - | 1535531..1536102 (+) | 572 | Protein_1520 | IS30 family transposase | - |
| IBC03_RS07930 (IBC03_07950) | - | 1536174..1536347 (-) | 174 | WP_011681546.1 | hypothetical protein | - |
| IBC03_RS07935 (IBC03_07955) | - | 1536408..1536782 (-) | 375 | WP_011681547.1 | membrane protein | - |
| IBC03_RS07940 (IBC03_07960) | pflA | 1536994..1537794 (-) | 801 | WP_071417327.1 | pyruvate formate-lyase-activating protein | - |
| IBC03_RS07945 (IBC03_07965) | - | 1537982..1538092 (-) | 111 | WP_014621906.1 | LPXTG cell wall anchor domain-containing protein | - |
| IBC03_RS07950 (IBC03_07970) | - | 1538790..1540121 (-) | 1332 | WP_024703987.1 | hemolysin family protein | - |
| IBC03_RS07955 (IBC03_07975) | - | 1540235..1541017 (+) | 783 | WP_024703988.1 | ABC transporter ATP-binding protein | - |
| IBC03_RS07960 (IBC03_07980) | - | 1541636..1543702 (-) | 2067 | WP_138496610.1 | sodium:proton antiporter | - |
| IBC03_RS07965 (IBC03_07985) | - | 1543711..1543953 (-) | 243 | WP_084830769.1 | hypothetical protein | - |
| IBC03_RS07970 (IBC03_07990) | - | 1543950..1544498 (-) | 549 | WP_011226462.1 | class I SAM-dependent methyltransferase | - |
| IBC03_RS07975 (IBC03_07995) | - | 1544495..1545439 (-) | 945 | WP_138496612.1 | TIGR01212 family radical SAM protein | - |
| IBC03_RS07980 (IBC03_08000) | sepM | 1545524..1546600 (-) | 1077 | WP_011681549.1 | SepM family pheromone-processing serine protease | Regulator |
| IBC03_RS07985 (IBC03_08005) | coaD | 1546578..1547075 (-) | 498 | WP_011681550.1 | pantetheine-phosphate adenylyltransferase | - |
| IBC03_RS07990 (IBC03_08010) | rsmD | 1547109..1547708 (-) | 600 | Protein_1533 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| IBC03_RS07995 (IBC03_08015) | trxB | 1547799..1548752 (-) | 954 | WP_259699870.1 | thioredoxin-disulfide reductase | - |
| IBC03_RS08000 (IBC03_08020) | - | 1548785..1549009 (-) | 225 | WP_082309114.1 | DUF4059 family protein | - |
| IBC03_RS08005 (IBC03_08025) | - | 1549224..1549967 (-) | 744 | WP_011681551.1 | amino acid ABC transporter ATP-binding protein | - |
| IBC03_RS08010 (IBC03_08030) | - | 1549967..1550713 (-) | 747 | WP_095559509.1 | amino acid ABC transporter permease | - |
| IBC03_RS08015 (IBC03_08035) | - | 1551109..1551939 (-) | 831 | WP_014608653.1 | transporter substrate-binding domain-containing protein | - |
| IBC03_RS08020 (IBC03_08040) | - | 1552399..1552632 (-) | 234 | WP_002947030.1 | hypothetical protein | - |
| IBC03_RS08025 (IBC03_08045) | dinB | 1552930..1554033 (-) | 1104 | WP_014608654.1 | DNA polymerase IV | - |
| IBC03_RS08030 (IBC03_08050) | pflB | 1554312..1556621 (+) | 2310 | WP_138496614.1 | formate C-acetyltransferase | - |
| IBC03_RS08035 (IBC03_08055) | - | 1556888..1557670 (+) | 783 | WP_011681555.1 | carbonic anhydrase family protein | - |
| IBC03_RS08040 (IBC03_08060) | - | 1557721..1558173 (+) | 453 | WP_014608655.1 | GNAT family N-acetyltransferase | - |
| IBC03_RS08045 (IBC03_08065) | - | 1558524..1558829 (-) | 306 | WP_014621914.1 | restriction endonuclease subunit S | - |
| IBC03_RS10590 (IBC03_08070) | mobV | 1558854..1559362 (-) | 509 | Protein_1545 | MobV family relaxase | - |
| IBC03_RS08055 (IBC03_08075) | fetB | 1559807..1560562 (-) | 756 | WP_011681558.1 | iron export ABC transporter permease subunit FetB | - |
| IBC03_RS08060 (IBC03_08080) | - | 1560559..1561209 (-) | 651 | WP_011681559.1 | ATP-binding cassette domain-containing protein | - |
| IBC03_RS08065 (IBC03_08085) | - | 1561412..1562368 (-) | 957 | WP_002951776.1 | serine hydrolase domain-containing protein | - |
| IBC03_RS08070 (IBC03_08090) | - | 1562368..1563123 (-) | 756 | WP_011681560.1 | CppA family protein | - |
| IBC03_RS08075 (IBC03_08095) | - | 1563405..1563767 (+) | 363 | WP_014608659.1 | CPBP family intramembrane glutamic endopeptidase | - |
| IBC03_RS08080 (IBC03_08100) | gla | 1563854..1564717 (-) | 864 | WP_002951781.1 | aquaglyceroporin Gla | - |
| IBC03_RS08085 (IBC03_08105) | - | 1564838..1567105 (+) | 2268 | WP_011681561.1 | Xaa-Pro dipeptidyl-peptidase | - |
| IBC03_RS08090 (IBC03_08110) | - | 1567185..1567565 (-) | 381 | WP_002951783.1 | hypothetical protein | - |
| IBC03_RS08095 (IBC03_08115) | - | 1567690..1567953 (-) | 264 | WP_002945924.1 | hypothetical protein | - |
| IBC03_RS08100 (IBC03_08120) | - | 1568275..1568571 (-) | 297 | WP_004197070.1 | bacteriocin immunity protein | - |
| IBC03_RS10310 | - | 1568736..1568867 (-) | 132 | WP_232659903.1 | LPXTG cell wall anchor domain-containing protein | - |
| IBC03_RS08110 (IBC03_08130) | - | 1568973..1569662 (-) | 690 | WP_011681563.1 | thioredoxin family protein | - |
| IBC03_RS08115 (IBC03_08135) | - | 1569856..1571426 (+) | 1571 | WP_087009847.1 | IS3-like element ISSth1b family transposase | - |
| IBC03_RS08120 (IBC03_08140) | - | 1571572..1571826 (-) | 255 | WP_014608660.1 | Blp family class II bacteriocin | - |
| IBC03_RS10595 | - | 1572077..1572478 (-) | 402 | WP_024703992.1 | hypothetical protein | - |
| IBC03_RS08125 (IBC03_08145) | - | 1573483..1573713 (-) | 231 | WP_014608662.1 | bacteriocin class II family protein | - |
| IBC03_RS08130 (IBC03_08150) | - | 1574069..1574269 (-) | 201 | WP_011681569.1 | hypothetical protein | - |
| IBC03_RS08135 (IBC03_08155) | - | 1574288..1574464 (-) | 177 | WP_011681570.1 | Blp family class II bacteriocin | - |
| IBC03_RS08140 (IBC03_08160) | - | 1574715..1575452 (+) | 738 | WP_011681571.1 | response regulator transcription factor | - |
| IBC03_RS10315 | - | 1575983..1576786 (+) | 804 | WP_223899638.1 | ATP-binding protein | - |
| IBC03_RS08150 (IBC03_08170) | - | 1576804..1576965 (-) | 162 | WP_011681573.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| IBC03_RS08155 (IBC03_08175) | - | 1576980..1578347 (-) | 1368 | WP_138496440.1 | bacteriocin secretion accessory protein | - |
| IBC03_RS08160 (IBC03_08180) | - | 1578363..1580515 (-) | 2153 | Protein_1568 | peptide cleavage/export ABC transporter | - |
| IBC03_RS08170 (IBC03_08190) | - | 1581529..1583274 (-) | 1746 | WP_024703994.1 | ABC transporter ATP-binding protein | - |
| IBC03_RS08175 (IBC03_08195) | - | 1583267..1585024 (-) | 1758 | WP_014608668.1 | ABC transporter transmembrane domain-containing protein | - |
| IBC03_RS10320 | - | 1585212..1585418 (-) | 207 | WP_002948879.1 | hypothetical protein | - |
| IBC03_RS08185 (IBC03_08205) | - | 1585623..1586150 (-) | 528 | WP_011226503.1 | VanZ family protein | - |
| IBC03_RS08190 (IBC03_08210) | rlmN | 1586152..1587321 (-) | 1170 | WP_011226504.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| IBC03_RS08195 (IBC03_08215) | - | 1587325..1588047 (-) | 723 | WP_011226505.1 | YutD family protein | - |
| IBC03_RS08200 (IBC03_08220) | - | 1588102..1589457 (-) | 1356 | WP_002948886.1 | metallophosphatase | - |
| IBC03_RS08210 (IBC03_08225) | - | 1590305..1591648 (-) | 1344 | WP_014608670.1 | DEAD/DEAH box helicase | - |
| IBC03_RS08215 (IBC03_08230) | mraY | 1591723..1592745 (-) | 1023 | WP_011227524.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| IBC03_RS08220 (IBC03_08235) | pbp2X | 1592747..1595014 (-) | 2268 | WP_011226508.1 | penicillin-binding protein PBP2X | - |
| IBC03_RS08225 (IBC03_08240) | ftsL | 1595018..1595338 (-) | 321 | WP_014608671.1 | cell division protein FtsL | - |
| IBC03_RS08230 (IBC03_08245) | rsmH | 1595341..1596291 (-) | 951 | WP_002888254.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| IBC03_RS08235 (IBC03_08250) | - | 1596458..1597189 (-) | 732 | WP_224103288.1 | hypothetical protein | - |
| IBC03_RS08245 (IBC03_08260) | - | 1597518..1597781 (+) | 264 | WP_162877224.1 | hypothetical protein | - |
| IBC03_RS08250 (IBC03_08265) | - | 1598087..1598443 (-) | 357 | WP_023909925.1 | DUF805 domain-containing protein | - |
| IBC03_RS08255 (IBC03_08270) | - | 1598792..1598959 (-) | 168 | WP_153300736.1 | hypothetical protein | - |
| IBC03_RS08260 (IBC03_08275) | - | 1599292..1600542 (-) | 1251 | WP_014608675.1 | glutamate-5-semialdehyde dehydrogenase | - |
| IBC03_RS08265 (IBC03_08280) | proB | 1600544..1601347 (-) | 804 | WP_014608676.1 | glutamate 5-kinase | - |
| IBC03_RS08270 (IBC03_08285) | - | 1601468..1603057 (-) | 1590 | WP_014608677.1 | ABC transporter permease | - |
Sequence
Protein
Download Length: 358 a.a. Molecular weight: 39172.02 Da Isoelectric Point: 9.3888
>NTDB_id=479836 IBC03_RS07980 WP_011681549.1 1545524..1546600(-) (sepM) [Streptococcus thermophilus strain 13496]
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
Nucleotide
Download Length: 1077 bp
>NTDB_id=479836 IBC03_RS07980 WP_011681549.1 1545524..1546600(-) (sepM) [Streptococcus thermophilus strain 13496]
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sepM | Streptococcus mutans UA159 |
62.757 |
95.251 |
0.598 |