Detailed information NTG0478391

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: H9Q14_RS10935
• Genome accession: NZ_CP060794
• Coordinates: 2277957..2279003 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain Z0118SE0260
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2272957..2284003

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H9Q14_RS10905	-	2273341..2274582 (-)	1242	WP_001832467.1	aminopeptidase	-
H9Q14_RS10910	-	2274584..2274799 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
H9Q14_RS10915	-	2274940..2275404 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
H9Q14_RS10920	-	2275412..2275696 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
H9Q14_RS10925	-	2276103..2277281 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
H9Q14_RS10930	vraR	2277338..2277967 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
H9Q14_RS10935	vraS	2277957..2279003 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
H9Q14_RS10940	liaF	2279000..2279701 (-)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
H9Q14_RS10945	-	2279716..2280102 (-)	387	WP_001830382.1	hypothetical protein	-
H9Q14_RS10950	map	2280260..2281015 (-)	756	WP_001830397.1	type I methionyl aminopeptidase	-
H9Q14_RS10955	-	2281189..2282175 (+)	987	WP_002457091.1	aromatic acid exporter family protein	-
H9Q14_RS10960	-	2282326..2282862 (-)	537	WP_145372832.1	hypothetical protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=478391 H9Q14_RS10935 WP_001830374.1 2277957..2279003(-) (vraS) [Staphylococcus epidermidis strain Z0118SE0260]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=478391 H9Q14_RS10935 WP_001830374.1 2277957..2279003(-) (vraS) [Staphylococcus epidermidis strain Z0118SE0260]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92