Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   H7786_RS05815 Genome accession   NZ_CP060649
Coordinates   1168630..1170435 (-) Length   601 a.a.
NCBI ID   WP_030126417.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY270     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1148370..1195430 1168630..1170435 within 0


Gene organization within MGE regions


Location: 1148370..1195430
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7786_RS05735 (H7786_05795) - 1148408..1149682 (-) 1275 WP_002989251.1 polysaccharide deacetylase family protein -
  H7786_RS05740 (H7786_05800) - 1149777..1151204 (-) 1428 WP_030126519.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  H7786_RS05745 (H7786_05805) ptsP 1151371..1153104 (-) 1734 WP_030126520.1 phosphoenolpyruvate--protein phosphotransferase -
  H7786_RS05750 (H7786_05810) - 1153109..1153372 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  H7786_RS05755 (H7786_05815) nrdH 1153765..1153983 (+) 219 WP_030126521.1 glutaredoxin-like protein NrdH -
  H7786_RS05760 (H7786_05820) nrdE 1154003..1156162 (+) 2160 WP_030126522.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  H7786_RS05765 (H7786_05825) nrdF 1156495..1157454 (+) 960 WP_030126523.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  H7786_RS05770 (H7786_05830) - 1157516..1158742 (+) 1227 WP_394376053.1 chloride channel protein -
  H7786_RS05775 (H7786_05835) - 1158881..1160024 (+) 1144 Protein_1107 IS3 family transposase -
  H7786_RS05780 (H7786_05840) - 1160117..1160812 (-) 696 WP_002995750.1 CPBP family intramembrane glutamic endopeptidase -
  H7786_RS05785 (H7786_05845) - 1160831..1161592 (-) 762 WP_030126419.1 DUF3169 family protein -
  H7786_RS05790 (H7786_05850) - 1161589..1161804 (-) 216 WP_002989220.1 helix-turn-helix transcriptional regulator -
  H7786_RS05795 (H7786_05855) alaS 1162163..1164781 (-) 2619 WP_030126418.1 alanine--tRNA ligase -
  H7786_RS05800 (H7786_05860) prsA 1165168..1166223 (-) 1056 WP_002984003.1 peptidylprolyl isomerase PrsA -
  H7786_RS05805 (H7786_05865) - 1166286..1166993 (-) 708 WP_002984000.1 O-methyltransferase -
  H7786_RS05810 (H7786_05870) - 1167059..1168255 (-) 1197 WP_002995765.1 OFA family MFS transporter -
  H7786_RS05815 (H7786_05875) pepF 1168630..1170435 (-) 1806 WP_030126417.1 oligoendopeptidase F Regulator
  H7786_RS05820 (H7786_05880) - 1170448..1171410 (-) 963 WP_002983995.1 competence protein CoiA -
  H7786_RS05825 (H7786_05885) - 1171705..1172421 (-) 717 WP_030126416.1 pseudouridine synthase -
  H7786_RS05830 (H7786_05890) nagB 1172495..1173244 (-) 750 WP_030126415.1 glucosamine-6-phosphate deaminase -
  H7786_RS05835 (H7786_05895) queA 1173446..1174474 (+) 1029 WP_011284937.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  H7786_RS05840 (H7786_05900) - 1174481..1175701 (+) 1221 WP_030126414.1 DUF3114 domain-containing protein -
  H7786_RS05845 (H7786_05905) - 1175815..1176405 (-) 591 WP_011528765.1 serine hydrolase -
  H7786_RS05850 (H7786_05910) - 1176402..1176650 (-) 249 WP_010922432.1 serine hydrolase -
  H7786_RS05855 (H7786_05915) - 1176635..1176862 (-) 228 WP_030126413.1 hypothetical protein -
  H7786_RS05860 (H7786_05920) sodA 1177029..1177634 (-) 606 WP_002983977.1 superoxide dismutase SodA -
  H7786_RS05865 (H7786_05925) holA 1177731..1178771 (-) 1041 WP_030126412.1 DNA polymerase III subunit delta -
  H7786_RS05870 (H7786_05930) - 1178842..1181085 (-) 2244 WP_030126411.1 DNA internalization-related competence protein ComEC/Rec2 -
  H7786_RS05875 (H7786_05935) - 1181066..1181728 (-) 663 WP_030126410.1 ComEA family DNA-binding protein -
  H7786_RS05880 (H7786_05940) - 1181928..1182668 (-) 741 WP_228646578.1 lysophospholipid acyltransferase family protein -
  H7786_RS05885 (H7786_05945) - 1182786..1183562 (+) 777 WP_010922438.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  H7786_RS05890 (H7786_05950) - 1183552..1183830 (+) 279 WP_002989164.1 GIY-YIG nuclease family protein -
  H7786_RS05895 (H7786_05955) - 1183854..1185854 (-) 2001 WP_030126409.1 potassium transporter Kup -
  H7786_RS05900 (H7786_05960) - 1185982..1187601 (-) 1620 WP_002989158.1 DEAD/DEAH box helicase -
  H7786_RS05905 (H7786_05965) - 1187908..1189452 (-) 1545 WP_002989155.1 peptide chain release factor 3 -
  H7786_RS05910 (H7786_05970) - 1189700..1190395 (-) 696 WP_030126408.1 TIGR02206 family membrane protein -
  H7786_RS05915 (H7786_05975) murF 1190475..1191866 (-) 1392 WP_010922441.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  H7786_RS05920 (H7786_05980) - 1192057..1193103 (-) 1047 WP_030126407.1 D-alanine--D-alanine ligase -
  H7786_RS05925 (H7786_05985) recR 1193204..1193800 (-) 597 WP_002983939.1 recombination mediator RecR -
  H7786_RS09160 - 1193847..1194038 (-) 192 WP_002983936.1 hypothetical protein -
  H7786_RS05930 (H7786_05990) - 1194599..1195378 (-) 780 WP_002989141.1 formate/nitrite transporter family protein -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69395.39 Da        Isoelectric Point: 4.7743

>NTDB_id=477534 H7786_RS05815 WP_030126417.1 1168630..1170435(-) (pepF) [Streptococcus pyogenes strain TSPY270]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADEIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=477534 H7786_RS05815 WP_030126417.1 1168630..1170435(-) (pepF) [Streptococcus pyogenes strain TSPY270]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATGAGATTGTGCATGGCACACAAGACGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Oligopeptidase F (Peptidase_M3_N)

(112-181)

Peptidase family M3 (Peptidase_M3)

(202-581)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

70.549

100

0.705