Detailed information    

insolico Bioinformatically predicted

Overview

Name   sepM   Type   Regulator
Locus tag   H7788_RS06130 Genome accession   NZ_CP060647
Coordinates   1211449..1212486 (-) Length   345 a.a.
NCBI ID   WP_002983824.1    Uniprot ID   A0A4U9C0Q7
Organism   Streptococcus pyogenes strain TSPY136     
Function   processing of CSP (predicted from homology)   
Competence regulation

Genomic Context

Location: 1206449..1217486
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7788_RS06110 (H7788_06105) - 1207199..1207825 (+) 627 WP_002989076.1 prepilin peptidase -
  H7788_RS06115 (H7788_06110) rlmN 1207907..1208987 (-) 1081 Protein_1168 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  H7788_RS06120 (H7788_06115) - 1208991..1209611 (-) 621 WP_002992791.1 YutD family protein -
  H7788_RS06125 (H7788_06120) - 1210059..1211035 (-) 977 Protein_1170 LacI family DNA-binding transcriptional regulator -
  H7788_RS06130 (H7788_06130) sepM 1211449..1212486 (-) 1038 WP_002983824.1 SepM family pheromone-processing serine protease Regulator
  H7788_RS06135 (H7788_06135) coaD 1212473..1212964 (-) 492 WP_030127407.1 pantetheine-phosphate adenylyltransferase -
  H7788_RS06140 (H7788_06140) rsmD 1212954..1213493 (-) 540 WP_002983819.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  H7788_RS06145 (H7788_06145) asnA 1213616..1214608 (-) 993 WP_002983817.1 aspartate--ammonia ligase -
  H7788_RS06150 (H7788_06150) arcC 1214921..1215871 (-) 951 WP_010922501.1 carbamate kinase -
  H7788_RS06155 (H7788_06155) - 1215891..1217222 (-) 1332 WP_011054719.1 dipeptidase -

Sequence

Protein


Download         Length: 345 a.a.        Molecular weight: 37555.27 Da        Isoelectric Point: 9.6692

>NTDB_id=477426 H7788_RS06130 WP_002983824.1 1211449..1212486(-) (sepM) [Streptococcus pyogenes strain TSPY136]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide


Download         Length: 1038 bp        

>NTDB_id=477426 H7788_RS06130 WP_002983824.1 1211449..1212486(-) (sepM) [Streptococcus pyogenes strain TSPY136]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGGAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGTGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

Lon protease (S16) C-terminal proteolytic domain (Lon_C)

(233-309)

PDZ domain (PDZ_2)

(129-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U9C0Q7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sepM Streptococcus mutans UA159

68.986

100

0.69