Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   H7788_RS01585 Genome accession   NZ_CP060647
Coordinates   300137..300823 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY136     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 295137..305823
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7788_RS01560 (H7788_01550) ktrB 295280..296656 (-) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -
  H7788_RS01565 (H7788_01555) rsmG 296740..297453 (-) 714 WP_011054198.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  H7788_RS01570 (H7788_01560) - 297603..298160 (+) 558 WP_002985956.1 LemA family protein -
  H7788_RS01575 (H7788_01565) htpX 298207..299103 (+) 897 WP_030127138.1 zinc metalloprotease HtpX -
  H7788_RS01580 (H7788_01570) - 299337..299870 (+) 534 WP_011017345.1 YceD family protein -
  H7788_RS01585 (H7788_01575) covR 300137..300823 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  H7788_RS01590 (H7788_01580) covS 300829..302331 (+) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  H7788_RS01595 (H7788_01585) nrdR 302546..303040 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  H7788_RS01600 (H7788_01590) - 303024..304199 (+) 1176 WP_030127140.1 replication initiation and membrane attachment family protein -
  H7788_RS01605 (H7788_01595) dnaI 304200..305102 (+) 903 WP_002991016.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=477407 H7788_RS01585 WP_002991052.1 300137..300823(+) (covR) [Streptococcus pyogenes strain TSPY136]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=477407 H7788_RS01585 WP_002991052.1 300137..300823(+) (covR) [Streptococcus pyogenes strain TSPY136]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425