Detailed information NTG0477146

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: H7793_RS03415
• Genome accession: NZ_CP060642
• Coordinates: 657961..658998 (+)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain TSPY1312
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 652961..663998

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7793_RS03390 (H7793_03400)	-	653225..654556 (+)	1332	WP_136021589.1	dipeptidase	-
H7793_RS03395 (H7793_03405)	arcC	654576..655526 (+)	951	WP_076634519.1	carbamate kinase	-
H7793_RS03400 (H7793_03410)	asnA	655839..656831 (+)	993	WP_136021588.1	aspartate--ammonia ligase	-
H7793_RS03405 (H7793_03415)	rsmD	656954..657493 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
H7793_RS03410 (H7793_03420)	coaD	657483..657974 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
H7793_RS03415 (H7793_03425)	sepM	657961..658998 (+)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
H7793_RS03420 (H7793_03430)	-	659403..660380 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
H7793_RS03425 (H7793_03435)	-	660828..661448 (+)	621	WP_168389441.1	YutD family protein	-
H7793_RS03430 (H7793_03440)	rlmN	661452..662531 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
H7793_RS03435 (H7793_03445)	-	662613..663239 (-)	627	WP_002983834.1	prepilin peptidase	-
H7793_RS03440 (H7793_03450)	-	663467..663994 (+)	528	WP_002983837.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=477146 H7793_RS03415 WP_002989068.1 657961..658998(+) (sepM) [Streptococcus pyogenes strain TSPY1312]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=477146 H7793_RS03415 WP_002989068.1 657961..658998(+) (sepM) [Streptococcus pyogenes strain TSPY1312]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTTGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69