Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   H7796_RS05280 Genome accession   NZ_CP060640
Coordinates   1076447..1078252 (-) Length   601 a.a.
NCBI ID   WP_011054652.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY764     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1056153..1103254 1076447..1078252 within 0


Gene organization within MGE regions


Location: 1056153..1103254
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7796_RS05200 (H7796_05215) - 1056191..1057465 (-) 1275 WP_014407660.1 polysaccharide deacetylase family protein -
  H7796_RS05205 (H7796_05220) - 1057560..1058987 (-) 1428 WP_020905280.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  H7796_RS05210 (H7796_05225) ptsP 1059172..1060905 (-) 1734 WP_002989245.1 phosphoenolpyruvate--protein phosphotransferase -
  H7796_RS05215 (H7796_05230) - 1060910..1061173 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  H7796_RS05220 (H7796_05235) - 1061566..1061784 (+) 219 WP_002989242.1 redoxin NrdH -
  H7796_RS05225 (H7796_05240) nrdE 1061804..1063963 (+) 2160 WP_020905281.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  H7796_RS05230 (H7796_05245) nrdF 1064296..1065255 (+) 960 WP_228631237.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  H7796_RS05235 (H7796_05250) - 1065317..1066543 (+) 1227 WP_021775375.1 chloride channel protein -
  H7796_RS05240 (H7796_05255) - 1066681..1067837 (+) 1157 Protein_995 IS3 family transposase -
  H7796_RS05245 (H7796_05260) - 1067931..1068626 (-) 696 WP_002989227.1 CPBP family intramembrane glutamic endopeptidase -
  H7796_RS05250 (H7796_05265) - 1068645..1069406 (-) 762 WP_228631238.1 DUF3169 family protein -
  H7796_RS05255 (H7796_05270) - 1069403..1069618 (-) 216 WP_002989220.1 helix-turn-helix transcriptional regulator -
  H7796_RS05260 (H7796_05275) alaS 1069979..1072597 (-) 2619 WP_020905288.1 alanine--tRNA ligase -
  H7796_RS05265 (H7796_05280) prsA 1072984..1074039 (-) 1056 WP_020905289.1 peptidylprolyl isomerase PrsA -
  H7796_RS05270 (H7796_05285) - 1074102..1074809 (-) 708 WP_002989211.1 O-methyltransferase -
  H7796_RS05275 (H7796_05290) - 1074875..1076071 (-) 1197 WP_002995765.1 OFA family MFS transporter -
  H7796_RS05280 (H7796_05295) pepF 1076447..1078252 (-) 1806 WP_011054652.1 oligoendopeptidase F Regulator
  H7796_RS05285 (H7796_05300) - 1078265..1079227 (-) 963 WP_002983995.1 competence protein CoiA -
  H7796_RS05290 (H7796_05305) - 1079522..1080238 (-) 717 WP_002989197.1 pseudouridine synthase -
  H7796_RS05295 (H7796_05310) nagB 1080357..1081061 (-) 705 WP_002989194.1 glucosamine-6-phosphate deaminase -
  H7796_RS05300 (H7796_05315) queA 1081263..1082291 (+) 1029 WP_011284937.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  H7796_RS05305 (H7796_05320) - 1082298..1083518 (+) 1221 WP_002989189.1 DUF3114 domain-containing protein -
  H7796_RS05310 (H7796_05325) - 1083632..1084222 (-) 591 WP_002989185.1 serine hydrolase -
  H7796_RS05315 (H7796_05330) - 1084219..1084467 (-) 249 WP_002989183.1 serine hydrolase -
  H7796_RS05320 (H7796_05335) - 1084523..1084678 (-) 156 WP_002989180.1 hypothetical protein -
  H7796_RS05325 (H7796_05340) sodA 1084845..1085450 (-) 606 WP_020905299.1 superoxide dismutase SodA -
  H7796_RS05330 (H7796_05345) holA 1085547..1086587 (-) 1041 WP_020905300.1 DNA polymerase III subunit delta -
  H7796_RS05335 (H7796_05350) - 1086658..1088901 (-) 2244 WP_136268042.1 DNA internalization-related competence protein ComEC/Rec2 -
  H7796_RS05340 (H7796_05355) - 1088882..1089544 (-) 663 WP_228631239.1 ComEA family DNA-binding protein -
  H7796_RS05345 (H7796_05360) - 1089744..1090484 (-) 741 WP_012560804.1 lysophospholipid acyltransferase family protein -
  H7796_RS05350 (H7796_05365) - 1090602..1091378 (+) 777 WP_002994360.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  H7796_RS05355 (H7796_05370) - 1091368..1091646 (+) 279 WP_228631240.1 GIY-YIG nuclease family protein -
  H7796_RS05360 (H7796_05375) - 1091670..1093670 (-) 2001 WP_228631241.1 potassium transporter Kup -
  H7796_RS05365 (H7796_05380) - 1093798..1095417 (-) 1620 WP_228631242.1 DEAD/DEAH box helicase -
  H7796_RS05370 (H7796_05385) - 1095724..1097268 (-) 1545 WP_020905306.1 peptide chain release factor 3 -
  H7796_RS05375 (H7796_05390) - 1097516..1098211 (-) 696 WP_011017956.1 TIGR02206 family membrane protein -
  H7796_RS05380 (H7796_05395) murF 1098291..1099682 (-) 1392 WP_011017957.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  H7796_RS05385 (H7796_05400) - 1099881..1100927 (-) 1047 WP_020905307.1 D-alanine--D-alanine ligase -
  H7796_RS05390 (H7796_05405) recR 1101028..1101624 (-) 597 WP_002983939.1 recombination mediator RecR -
  H7796_RS08515 - 1101671..1101862 (-) 192 WP_002983936.1 hypothetical protein -
  H7796_RS05395 (H7796_05410) - 1102423..1103202 (-) 780 WP_021775443.1 formate/nitrite transporter family protein -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69341.19 Da        Isoelectric Point: 4.7093

>NTDB_id=477047 H7796_RS05280 WP_011054652.1 1076447..1078252(-) (pepF) [Streptococcus pyogenes strain TSPY764]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=477047 H7796_RS05280 WP_011054652.1 1076447..1078252(-) (pepF) [Streptococcus pyogenes strain TSPY764]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAATT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAGGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCAG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(202-581)

Oligopeptidase F (Peptidase_M3_N)

(112-181)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

71.215

100

0.712