Detailed information NTG0476942

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: H7798_RS06200
• Genome accession: NZ_CP060638
• Coordinates: 1258981..1260018 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain TSPY141
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1253981..1265018

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7798_RS06175 (H7798_06205)	-	1253994..1254521 (-)	528	WP_002983837.1	Dps family protein	-
H7798_RS06180 (H7798_06210)	-	1254749..1255375 (+)	627	WP_030126387.1	prepilin peptidase	-
H7798_RS06185 (H7798_06215)	rlmN	1255457..1256517 (-)	1061	Protein_1201	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
H7798_RS06190 (H7798_06220)	-	1256521..1257141 (-)	621	WP_002992791.1	YutD family protein	-
H7798_RS06195 (H7798_06225)	-	1257589..1258566 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
H7798_RS06200 (H7798_06230)	sepM	1258981..1260018 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
H7798_RS06205 (H7798_06235)	coaD	1260005..1260496 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
H7798_RS06210 (H7798_06240)	rsmD	1260486..1261025 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
H7798_RS06215 (H7798_06245)	asnA	1261148..1262140 (-)	993	WP_023611792.1	aspartate--ammonia ligase	-
H7798_RS06220 (H7798_06250)	arcC	1262453..1263403 (-)	951	WP_010922501.1	carbamate kinase	-
H7798_RS06225 (H7798_06255)	-	1263423..1264754 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=476942 H7798_RS06200 WP_002983824.1 1258981..1260018(-) (sepM) [Streptococcus pyogenes strain TSPY141]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=476942 H7798_RS06200 WP_002983824.1 1258981..1260018(-) (sepM) [Streptococcus pyogenes strain TSPY141]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGCAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69