Detailed information NTG0476674

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: H9M95_RS04425
• Genome accession: NZ_CP060584
• Coordinates: 908538..909581 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain WH52
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 903538..914581

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H9M95_RS04395 (H9M95_04400)	-	903908..904018 (+)	111	WP_001790257.1	hypothetical protein	-
H9M95_RS04400 (H9M95_04405)	-	904047..904460 (+)	414	WP_001549145.1	hypothetical protein	-
H9M95_RS04405 (H9M95_04410)	-	904891..905877 (-)	987	WP_000999713.1	FUSC family protein	-
H9M95_RS04410 (H9M95_04415)	map	906464..907222 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
H9M95_RS04415 (H9M95_04420)	-	907439..907825 (+)	387	WP_001110179.1	hypothetical protein	-
H9M95_RS04420 (H9M95_04425)	liaF	907840..908541 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
H9M95_RS04425 (H9M95_04430)	vraS	908538..909581 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
H9M95_RS04430 (H9M95_04435)	vraR	909571..910200 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
H9M95_RS04435 (H9M95_04440)	-	910316..911527 (-)	1212	WP_194251086.1	YihY/virulence factor BrkB family protein	-
H9M95_RS04440 (H9M95_04445)	-	911805..912080 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
H9M95_RS04445 (H9M95_04450)	-	912087..912551 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
H9M95_RS04450 (H9M95_04455)	-	912698..912898 (+)	201	WP_000180461.1	DUF1128 family protein	-
H9M95_RS04455 (H9M95_04460)	-	912901..914157 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=476674 H9M95_RS04425 WP_001017131.1 908538..909581(+) (vraS) [Staphylococcus aureus strain WH52]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=476674 H9M95_RS04425 WP_001017131.1 908538..909581(+) (vraS) [Staphylococcus aureus strain WH52]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1