Detailed information NTG0476648

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: HUG14_RS03090
• Genome accession: NZ_CP060580
• Coordinates: 628478..629506 (-)
• Length: 342 a.a.
• NCBI ID: WP_003132657.1
• Uniprot ID: S6FVM6
• Organism: Lactococcus lactis strain K_LL005
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 623478..634506

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HUG14_RS03060 (HUG14_03060)	-	623745..624467 (-)	723	WP_033900892.1	ABC transporter permease	-
HUG14_RS03065 (HUG14_03065)	-	624469..625320 (-)	852	WP_033900890.1	ABC transporter ATP-binding protein	-
HUG14_RS03070 (HUG14_03070)	-	625317..626582 (-)	1266	WP_033900888.1	radical SAM/SPASM domain-containing protein	-
HUG14_RS03075 (HUG14_03075)	-	626906..627172 (-)	267	WP_187398486.1	hypothetical protein	-
HUG14_RS03080 (HUG14_03080)	-	627227..627418 (-)	192	WP_136122481.1	hypothetical protein	-
HUG14_RS03085 (HUG14_03085)	-	627501..628358 (-)	858	WP_033900885.1	Rgg/GadR/MutR family transcriptional regulator	-
HUG14_RS03090 (HUG14_03090)	sepM	628478..629506 (-)	1029	WP_003132657.1	SepM family pheromone-processing serine protease	Regulator
HUG14_RS03095 (HUG14_03095)	coaD	629493..629990 (-)	498	WP_010906348.1	pantetheine-phosphate adenylyltransferase	-
HUG14_RS03100 (HUG14_03100)	rsmD	630038..630577 (-)	540	WP_015427191.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
HUG14_RS03105 (HUG14_03105)	-	630748..631968 (-)	1221	WP_012898647.1	MFS transporter	-
HUG14_RS03110 (HUG14_03110)	lmrP	632051..633277 (-)	1227	WP_033900880.1	multidrug efflux MFS transporter LmrP	-

Sequence

Protein

• Length: 342 a.a.
• Molecular weight: 37349.96 Da
• Isoelectric Point: 9.9183

>NTDB_id=476648 HUG14_RS03090 WP_003132657.1 628478..629506(-) (sepM) [Lactococcus lactis strain K_LL005]
MKKNKKINPKLKWGISIGLIVVALLALFYPTSYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYSH
FNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAIYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELADTITAV
NGQQFTSSADMIAYVSKQKVGDSVTIEYTRIDGTKHKSTGKYIKIANGKTGIGISLVDHTEVVTTPKVTVNAGSIGGPSA
GMMFTLEIYSQLTGKDLRNGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAKK
LKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1029 bp

>NTDB_id=476648 HUG14_RS03090 WP_003132657.1 628478..629506(-) (sepM) [Lactococcus lactis strain K_LL005]
ATGAAAAAAAATAAAAAAATTAATCCCAAATTAAAATGGGGAATCTCGATTGGTCTAATTGTTGTTGCCCTTTTAGCTTT
ATTTTACCCAACAAGTTACTATGTGGAAATGCCCGGAACAACCGAGCCTTTAGGGAAAATGGTCAAAGTTGAAGGCAAAA
AAGATGAACATAAAGGTGATTTTTTTCTGACGACTGTCCAAATTGCACGAGCAAATCTTGCTACAATGATTTACAGCCAT
TTTAATAGTTTTACAAGCATTTACAGTGAGCAAGAAATGACTGGTGGACTTAACGACGCACAGTTCAACCGTGTCAACCA
GTTTTACATGGAAACGGCACAGAATACAGCGATTTATCAAGCTTTTAAATTAGCTAATAAACCTTATGAGCTTAAATATG
AAGGCGTTTATGTCCTTGATATTGCCAAAAATTCGACCTTTAAAAATAAGCTAGAACTTGCAGATACGATTACAGCAGTC
AATGGTCAACAGTTTACATCAAGTGCCGACATGATTGCTTATGTTTCCAAACAAAAAGTCGGTGATTCAGTAACGATTGA
ATACACGAGAATTGACGGCACAAAGCACAAGTCAACTGGCAAATACATCAAAATTGCTAATGGTAAAACAGGAATAGGGA
TTAGCCTAGTTGACCATACTGAAGTCGTGACGACTCCGAAAGTTACTGTCAACGCGGGTTCAATCGGTGGTCCCTCTGCG
GGGATGATGTTTACACTAGAAATTTACAGTCAGTTGACAGGAAAAGATTTGCGAAACGGTCGCGAAATTGCTGGAACTGG
GACGATTGAACACGACGGAAGCATTGGTCAAATCGGCGGTGTTGATAAAAAAGTAGCCACAGCGAGTAAAGAAGGGGCAA
AGGTCTTCTTAGTGCCTGACTCAGGCACCAAAAAGGAAAGTAGCAACAATTACCTTGGAGCCAAAGCCGCAGCTAAAAAA
CTAAAAACGAAGATGAAAATCGTTCCCGTCAAAACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (134-194)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (227-338)

3D structure

• AlphaFold DB: S6FVM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.491