Detailed information NTG0476302

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: H8N04_RS04735
• Genome accession: NZ_CP060491
• Coordinates: 943851..944894 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain WH39
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 938851..949894

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H8N04_RS04705 (H8N04_04710)	-	939221..939331 (+)	111	WP_001790257.1	hypothetical protein	-
H8N04_RS04710 (H8N04_04715)	-	939360..939773 (+)	414	WP_001549145.1	hypothetical protein	-
H8N04_RS04715 (H8N04_04720)	-	940204..941190 (-)	987	WP_000999713.1	FUSC family protein	-
H8N04_RS04720 (H8N04_04725)	map	941777..942535 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
H8N04_RS04725 (H8N04_04730)	-	942752..943138 (+)	387	WP_001110179.1	hypothetical protein	-
H8N04_RS04730 (H8N04_04735)	liaF	943153..943854 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
H8N04_RS04735 (H8N04_04740)	vraS	943851..944894 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
H8N04_RS04740 (H8N04_04745)	vraR	944884..945513 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
H8N04_RS04745 (H8N04_04750)	-	945629..946846 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
H8N04_RS04750 (H8N04_04755)	-	947124..947399 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
H8N04_RS04755 (H8N04_04760)	-	947406..947870 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
H8N04_RS04760 (H8N04_04765)	-	948017..948217 (+)	201	WP_000180461.1	DUF1128 family protein	-
H8N04_RS04765 (H8N04_04770)	-	948220..949476 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=476302 H8N04_RS04735 WP_001017131.1 943851..944894(+) (vraS) [Staphylococcus aureus strain WH39]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=476302 H8N04_RS04735 WP_001017131.1 943851..944894(+) (vraS) [Staphylococcus aureus strain WH39]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1