Detailed information NTG0047594

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: CVCAS_RS11160
• Genome accession: NC_017486
• Coordinates: 2227277..2228305 (-)
• Length: 342 a.a.
• NCBI ID: WP_003132657.1
• Uniprot ID: S6FVM6
• Organism: Lactococcus lactis subsp. lactis CV56
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2222277..2233305

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CVCAS_RS11135 (CVCAS_2185)	-	2222563..2223060 (-)	498	WP_003132662.1	nitroreductase family protein	-
CVCAS_RS11140 (CVCAS_2186)	-	2223047..2223256 (-)	210	WP_003132661.1	hypothetical protein	-
CVCAS_RS11145 (CVCAS_2187)	-	2223253..2224080 (-)	828	WP_014570829.1	radical SAM protein	-
CVCAS_RS11150 (CVCAS_2188)	-	2224073..2226196 (-)	2124	WP_003132659.1	radical SAM protein	-
CVCAS_RS11155 (CVCAS_2189)	-	2226299..2227156 (-)	858	WP_003132658.1	Rgg/GadR/MutR family transcriptional regulator	-
CVCAS_RS11160 (CVCAS_2190)	sepM	2227277..2228305 (-)	1029	WP_003132657.1	SepM family pheromone-processing serine protease	Regulator
CVCAS_RS11165 (CVCAS_2191)	coaD	2228292..2228789 (-)	498	WP_010906348.1	pantetheine-phosphate adenylyltransferase	-
CVCAS_RS11170 (CVCAS_2192)	rsmD	2228837..2229376 (-)	540	WP_003132655.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
CVCAS_RS11175 (CVCAS_2193)	-	2229547..2230767 (-)	1221	WP_003132654.1	MFS transporter	-
CVCAS_RS11180 (CVCAS_2194)	lmrP	2230851..2232075 (-)	1225	Protein_2178	multidrug efflux MFS transporter LmrP	-
CVCAS_RS11185 (CVCAS_2195)	-	2232263..2232757 (+)	495	WP_012898649.1	RNA polymerase sigma factor	-

Sequence

Protein

• Length: 342 a.a.
• Molecular weight: 37349.96 Da
• Isoelectric Point: 9.9183

>NTDB_id=47594 CVCAS_RS11160 WP_003132657.1 2227277..2228305(-) (sepM) [Lactococcus lactis subsp. lactis CV56]
MKKNKKINPKLKWGISIGLIVVALLALFYPTSYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYSH
FNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAIYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELADTITAV
NGQQFTSSADMIAYVSKQKVGDSVTIEYTRIDGTKHKSTGKYIKIANGKTGIGISLVDHTEVVTTPKVTVNAGSIGGPSA
GMMFTLEIYSQLTGKDLRNGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAKK
LKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1029 bp

>NTDB_id=47594 CVCAS_RS11160 WP_003132657.1 2227277..2228305(-) (sepM) [Lactococcus lactis subsp. lactis CV56]
ATGAAAAAAAATAAAAAAATTAATCCCAAATTAAAATGGGGAATCTCGATTGGTCTAATTGTTGTTGCCCTTTTAGCTTT
ATTTTATCCAACAAGTTACTATGTGGAAATGCCCGGAACAACCGAGCCTTTAGGAAAAATGGTCAAAGTTGAAGGCAAAA
AAGATGAACATAAAGGTGATTTTTTCCTGACGACTGTCCAAATTGCACGAGCAAATCTTGCTACAATGATTTACAGCCAT
TTTAATAGTTTTACAAGCATTTACAGTGAGCAAGAAATGACTGGTGGACTTAACGACGCACAGTTCAACCGTGTCAACCA
GTTTTACATGGAAACGGCACAGAATACAGCGATTTATCAAGCTTTTAAATTAGCTAATAAACCTTATGAACTTAAATATG
AAGGCGTTTATGTCCTTGATATTGCCAAAAATTCGACCTTTAAAAATAAGCTAGAACTTGCAGATACGATTACAGCAGTC
AATGGTCAACAGTTTACATCAAGTGCCGACATGATTGCTTATGTTTCCAAACAAAAAGTCGGTGATTCAGTAACGATTGA
ATACACGAGAATTGACGGCACAAAGCACAAGTCAACTGGCAAATACATCAAAATTGCTAATGGAAAAACAGGAATTGGGA
TCAGCCTAGTTGACCATACTGAAGTCGTGACGACTCCAAAAGTTACTGTCAACGCGGGTTCAATCGGTGGTCCCTCTGCG
GGGATGATGTTTACACTAGAAATTTACAGTCAGTTGACAGGAAAAGATTTGCGAAACGGTCGCGAAATTGCTGGAACTGG
GACGATTGAACATGACGGAAGCATTGGCCAAATCGGCGGTGTTGATAAAAAAGTAGCCACAGCGAGCAAAGAAGGGGCAA
AGGTCTTCTTGGTGCCTGACTCAGGCACCAAAAAAGAAAGTAGCAACAATTACCTTGGAGCCAAAGCCGCCGCTAAAAAA
CTAAAAACGAAGATGAAAATCGTTCCCGTCAAAACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (134-194)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (227-338)

3D structure

• AlphaFold DB: S6FVM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.491