Detailed information NTG0475177

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: H7684_RS11405
• Genome accession: NZ_CP060278
• Coordinates: 2346263..2347306 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain KZN
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2341263..2352306

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7684_RS11375 (H7684_11375)	-	2341684..2342940 (-)	1257	WP_001795108.1	aminopeptidase	-
H7684_RS11380 (H7684_11380)	-	2342943..2343143 (-)	201	WP_000180460.1	DUF1128 family protein	-
H7684_RS11385 (H7684_11385)	-	2343290..2343754 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
H7684_RS11390 (H7684_11390)	-	2343761..2344036 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
H7684_RS11395 (H7684_11395)	-	2344314..2345531 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
H7684_RS11400 (H7684_11400)	vraR	2345644..2346273 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
H7684_RS11405 (H7684_11405)	vraS	2346263..2347306 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
H7684_RS11410 (H7684_11410)	liaF	2347303..2348004 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
H7684_RS11415 (H7684_11415)	-	2348019..2348405 (-)	387	WP_001110179.1	hypothetical protein	-
H7684_RS11420 (H7684_11420)	map	2348622..2349380 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
H7684_RS11425 (H7684_11425)	-	2349911..2350897 (+)	987	WP_031768943.1	aromatic acid exporter family protein	-
H7684_RS11430 (H7684_11430)	-	2351328..2351741 (-)	414	WP_001557448.1	hypothetical protein	-
H7684_RS11435 (H7684_11435)	-	2351770..2351880 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=475177 H7684_RS11405 WP_001017131.1 2346263..2347306(-) (vraS) [Staphylococcus aureus strain KZN]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=475177 H7684_RS11405 WP_001017131.1 2346263..2347306(-) (vraS) [Staphylococcus aureus strain KZN]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1