Detailed information NTG0471306

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: H3V22_RS08970
• Genome accession: NZ_CP059679
• Coordinates: 1788310..1789659 (+)
• Length: 449 a.a.
• NCBI ID: WP_107556507.1
• Uniprot ID: -
• Organism: Mammaliicoccus lentus strain H29
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	1789680..1809476	1788310..1789659	flank	21

Gene organization within MGE regions

Location: 1788310..1809476

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H3V22_RS08970 (H3V22_08965)	ccrA	1788310..1789659 (+)	1350	WP_107556507.1	cassette chromosome recombinase CcrA	Machinery gene
H3V22_RS08975 (H3V22_08970)	ccrB	1789680..1791308 (+)	1629	WP_001186596.1	cassette chromosome recombinase CcrB	Machinery gene
H3V22_RS08980 (H3V22_08975)	-	1791779..1792129 (+)	351	WP_000171449.1	SAUGI family uracil-DNA glycosylase inhibitor	-
H3V22_RS08985 (H3V22_08980)	-	1792214..1792525 (+)	312	WP_000833212.1	DUF960 family protein	-
H3V22_RS08990 (H3V22_08985)	-	1792544..1793065 (+)	522	WP_000836008.1	DUF1643 domain-containing protein	-
H3V22_RS08995 (H3V22_08990)	-	1793067..1793273 (+)	207	WP_001077283.1	hypothetical protein	-
H3V22_RS09000 (H3V22_08995)	-	1793266..1793589 (+)	324	WP_000088091.1	JAB domain-containing protein	-
H3V22_RS09005 (H3V22_09000)	-	1793784..1795676 (+)	1893	WP_182093640.1	site-specific integrase	-
H3V22_RS09010 (H3V22_09005)	-	1795683..1796060 (+)	378	WP_001041908.1	DUF6262 family protein	-
H3V22_RS09015 (H3V22_09010)	-	1796298..1796663 (+)	366	WP_000159127.1	ArsR/SmtB family transcription factor	-
H3V22_RS09020 (H3V22_09015)	-	1796656..1799070 (+)	2415	WP_182093641.1	cadmium-translocating P-type ATPase CadA	-
H3V22_RS09025 (H3V22_09020)	-	1799150..1799766 (+)	617	Protein_1759	CadD family cadmium resistance transporter	-
H3V22_RS09035 (H3V22_09030)	-	1800040..1800678 (-)	639	Protein_1760	sulfite exporter TauE/SafE family protein	-
H3V22_RS09040 (H3V22_09035)	cstR	1800678..1800938 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
H3V22_RS09045 (H3V22_09040)	-	1801074..1802138 (+)	1065	WP_182093642.1	DsrE/DsrF/DrsH-like family protein	-
H3V22_RS09050 (H3V22_09045)	cstB	1802173..1803507 (+)	1335	Protein_1763	persulfide dioxygenase-sulfurtransferase CstB	-
H3V22_RS09055 (H3V22_09050)	-	1803621..1804730 (-)	1110	WP_000943131.1	ROK family transcriptional regulator	-
H3V22_RS09060 (H3V22_09055)	psm-mec	1805089..1805157 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
H3V22_RS09065 (H3V22_09060)	mecI	1805242..1805613 (-)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
H3V22_RS09070 (H3V22_09065)	mecR1	1805613..1807370 (-)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
H3V22_RS09075 (H3V22_09070)	mecA	1807467..1809476 (+)	2010	WP_063852655.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52323.06 Da
• Isoelectric Point: 10.1180

>NTDB_id=471306 H3V22_RS08970 WP_107556507.1 1788310..1789659(+) (ccrA) [Mammaliicoccus lentus strain H29]
MKQAIGYLRQSTTKQQSLTAQKQTIETLAKKYNIQHITFYSDKQSGRTDNRTGYQQVIERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSIHDGYFDMDKAFDRLKLNIFISLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYTYR
NGTFTINQDEAPTVKAIFHYYLQDYGYKKIAQYLEKDDKCINRKPYQVRAIITNPNYCGRVINQYGQYDNMFPSIISTNI
YEQAQAIRSQKHTKRTPSDNQLQKKIKCPYCGSTLTNMTIRKKHHMLRYYACPQNMNASRFVCAFKGINAQVLETSVLAT
CQDFFQNQQLYSKINHTIQQRLKKQRDIEGKHTLTQEQLIDKLAKGMIDAETFRNQSQSVLQKRKNISSISDTQLQTSLQ
KVIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=471306 H3V22_RS08970 WP_107556507.1 1788310..1789659(+) (ccrA) [Mammaliicoccus lentus strain H29]
ATGAAACAAGCTATTGGTTATTTACGCCAAAGTACAACCAAGCAACAATCACTCACTGCACAGAAACAAACTATCGAAAC
GCTCGCTAAAAAATACAATATTCAACACATCACCTTTTATAGTGATAAGCAATCAGGCAGAACGGATAATCGAACGGGTT
ACCAACAAGTTATCGAACGCATTCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTAAATCGATTACATCGTAAT
TTGAAAAATGCATTAAAACTTATGAAACTGTGTCAAAAATATCATGTTCATATTCTAAGTATTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAGCTCAATATATTCATAAGTCTCGCAGAATTAGAGTCCGATAATATTGGTGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATCACGACACATGCACCATTTGGTTATACCTATCGC
AATGGCACATTCACAATTAATCAAGATGAAGCACCAACGGTTAAGGCAATATTCCATTACTACCTACAAGACTATGGTTA
TAAGAAAATTGCGCAATACCTAGAAAAAGATGATAAATGTATTAATCGTAAACCCTACCAAGTACGCGCTATTATCACGA
ATCCTAATTATTGTGGTCGCGTTATCAATCAATATGGACAATATGACAACATGTTCCCATCTATTATTTCGACCAATATA
TACGAACAAGCTCAAGCAATACGGTCACAAAAACATACCAAACGGACTCCATCAGATAATCAACTTCAGAAGAAAATAAA
ATGTCCATATTGTGGATCAACCCTGACTAATATGACGATTAGAAAAAAGCACCATATGTTACGTTATTATGCTTGTCCTC
AAAATATGAATGCATCACGTTTTGTCTGTGCATTCAAAGGAATCAATGCGCAAGTATTAGAAACAAGTGTCTTAGCGACT
TGTCAGGACTTCTTTCAGAACCAACAGCTCTATTCAAAAATCAACCATACAATTCAACAACGACTCAAAAAACAAAGGGA
CATAGAAGGTAAACATACACTCACGCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAAACATTCA
GGAATCAGTCTCAATCAGTGCTTCAAAAGCGCAAAAACATATCCTCAATAAGTGATACTCAGTTGCAAACATCACTACAA
AAGGTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCT
TGTTGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

• Resolvase, N terminal domain (Resolvase) (4-147)

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus COL	81.514	100	0.815
ccrA	Staphylococcus aureus N315	73.274	100	0.733