Detailed information NTG0047073

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: M1GAS476_RS08285
• Genome accession: NC_020540
• Coordinates: 1649693..1650433 (-)
• Length: 246 a.a.
• NCBI ID: WP_002986100.1
• Uniprot ID: A0A0H2UT50
• Organism: Streptococcus pyogenes M1 476
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1644693..1655433

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M1GAS476_RS08260 (M1GAS476_1744)	-	1645648..1646352 (-)	705	WP_010921873.1	N-acetylmannosamine-6-phosphate 2-epimerase	-
M1GAS476_RS08265	rpmH	1646626..1646760 (-)	135	WP_002885866.1	50S ribosomal protein L34	-
M1GAS476_RS08270 (M1GAS476_1746)	jag	1647075..1647989 (-)	915	WP_010921872.1	RNA-binding cell elongation regulator Jag/EloR	-
M1GAS476_RS08275 (M1GAS476_1747)	-	1648001..1648828 (-)	828	WP_010921871.1	YidC/Oxa1 family membrane protein insertase	-
M1GAS476_RS08280 (M1GAS476_1748)	rnpA	1648794..1649153 (-)	360	WP_002992035.1	ribonuclease P protein component	-
M1GAS476_RS08285 (M1GAS476_1749)	comE/blpR	1649693..1650433 (-)	741	WP_002986100.1	response regulator transcription factor	Regulator
M1GAS476_RS08290 (M1GAS476_1750)	-	1650437..1651720 (-)	1284	WP_010921869.1	sensor histidine kinase	-
M1GAS476_RS08295 (M1GAS476_1751)	-	1651717..1653063 (-)	1347	WP_011285380.1	sensor histidine kinase	-
M1GAS476_RS08300 (M1GAS476_1752)	gltX	1653458..1654903 (-)	1446	WP_002986105.1	glutamate--tRNA ligase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28881.47 Da
• Isoelectric Point: 6.4841

>NTDB_id=47073 M1GAS476_RS08285 WP_002986100.1 1649693..1650433(-) (comE/blpR) [Streptococcus pyogenes M1 476]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=47073 M1GAS476_RS08285 WP_002986100.1 1649693..1650433(-) (comE/blpR) [Streptococcus pyogenes M1 476]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A0H2UT50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37