Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HPSNT_RS04110 Genome accession   NC_017376
Coordinates   866546..868330 (+) Length   594 a.a.
NCBI ID   WP_000774399.1    Uniprot ID   G2MC46
Organism   Helicobacter pylori SNT49     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 861546..873330
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HPSNT_RS04075 (HPSNT_04220) - 861600..861947 (+) 348 Protein_795 osmoprotection protein -
  HPSNT_RS04080 (HPSNT_04225) - 861961..862533 (-) 573 WP_000916860.1 Hpy99I family type II restriction endonuclease -
  HPSNT_RS04085 (HPSNT_04230) - 862527..863345 (-) 819 WP_000125518.1 DNA-methyltransferase -
  HPSNT_RS04090 (HPSNT_04240) - 863595..865256 (+) 1662 WP_001139673.1 ABC transporter permease/substrate-binding protein -
  HPSNT_RS04095 (HPSNT_04245) - 865260..865901 (+) 642 WP_000659435.1 ATP-binding cassette domain-containing protein -
  HPSNT_RS04100 - 865913..866092 (-) 180 WP_000468794.1 hypothetical protein -
  HPSNT_RS04105 (HPSNT_04250) - 866084..866545 (+) 462 WP_000437223.1 hypothetical protein -
  HPSNT_RS04110 (HPSNT_04255) uvrC 866546..868330 (+) 1785 WP_000774399.1 excinuclease ABC subunit UvrC Machinery gene
  HPSNT_RS04115 (HPSNT_04260) - 868341..869606 (+) 1266 WP_000746790.1 homoserine dehydrogenase -
  HPSNT_RS04120 (HPSNT_04265) - 869607..869951 (+) 345 WP_001211652.1 YraN family protein -
  HPSNT_RS04125 (HPSNT_04270) trxA 870040..870360 (+) 321 WP_000020203.1 thioredoxin -
  HPSNT_RS04130 (HPSNT_04275) trxB 870366..871301 (+) 936 WP_000564425.1 thioredoxin-disulfide reductase -
  HPSNT_RS04135 (HPSNT_04280) - 871521..872342 (+) 822 WP_001263347.1 glycosyltransferase family 25 protein -
  HPSNT_RS04140 (HPSNT_04285) - 872542..872790 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68627.82 Da        Isoelectric Point: 9.6284

>NTDB_id=47030 HPSNT_RS04110 WP_000774399.1 866546..868330(+) (uvrC) [Helicobacter pylori SNT49]
MADLLSSLKNLSNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSVRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAVINHYQSHLPLIPEQILLN
ACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKISNEDLILEEARSLFELECIPYRVEIFDT
SHHANSQCVGGMVVYENNAFQKNSYRHYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=47030 HPSNT_RS04110 WP_000774399.1 866546..868330(+) (uvrC) [Helicobacter pylori SNT49]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTAACAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
GCTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAGAGCTATTTTTCTGTCCGTAATAATGAAATCACGCCCA
ACCATCGCGCAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACGATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCCTATATTTACATGGATTTTTCCACCGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAACAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAGGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAACAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGACATTTTCGCTTTTTATGGCGCAAGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTCAACGGGTTTGACA
CCGATGAAGCGATGAAACAAGCCGTTATCAACCATTACCAATCGCATTTGCCTTTGATACCAGAACAGATTTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAATTTATCTCCCATCAATACTCTAAAAAAATCGCTCTTAGTATTCC
TAAAAAAGGCGACAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAATCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTGAATTAGAGTGCATTCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCTAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAATGCATTCCAAAAAAACTCTTATCGGCA
CTACCATTTGAAAGGTTCTAATGAATACACCCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGCTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB G2MC46

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.98

100

0.98

Multiple sequence alignment