Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HMPREF0462_RS02840 Genome accession   NC_017375
Coordinates   567241..569025 (-) Length   594 a.a.
NCBI ID   WP_000774354.1    Uniprot ID   F4D5B5
Organism   Helicobacter pylori 83     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 562241..574025
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF0462_RS02810 (HMPREF0462_0579) - 562828..563076 (+) 249 WP_000790557.1 RNA-binding protein -
  HMPREF0462_RS02815 (HMPREF0462_0580) - 563282..564103 (-) 822 WP_001263426.1 glycosyltransferase family 25 protein -
  HMPREF0462_RS02820 (HMPREF0462_0581) trxB 564270..565205 (-) 936 WP_000564370.1 thioredoxin-disulfide reductase -
  HMPREF0462_RS02825 (HMPREF0462_0582) trxA 565211..565531 (-) 321 WP_000020199.1 thioredoxin -
  HMPREF0462_RS02830 (HMPREF0462_0583) - 565620..565964 (-) 345 WP_001211650.1 YraN family protein -
  HMPREF0462_RS02835 (HMPREF0462_0584) - 565965..567230 (-) 1266 WP_000746794.1 homoserine dehydrogenase -
  HMPREF0462_RS02840 (HMPREF0462_0585) uvrC 567241..569025 (-) 1785 WP_000774354.1 excinuclease ABC subunit UvrC Machinery gene
  HMPREF0462_RS02845 (HMPREF0462_0586) - 569026..569487 (-) 462 WP_000437202.1 hypothetical protein -
  HMPREF0462_RS02850 (HMPREF0462_0587) - 569479..569658 (+) 180 WP_000468796.1 hypothetical protein -
  HMPREF0462_RS02855 (HMPREF0462_0588) - 569670..570311 (-) 642 WP_000659327.1 ATP-binding cassette domain-containing protein -
  HMPREF0462_RS02860 (HMPREF0462_0589) - 570313..571974 (-) 1662 WP_014536464.1 ABC transporter permease/substrate-binding protein -
  HMPREF0462_RS02865 (HMPREF0462_0590) - 572154..572591 (-) 438 WP_001031790.1 hypothetical protein -
  HMPREF0462_RS02870 (HMPREF0462_0591) motB 572595..573362 (-) 768 WP_001085319.1 flagellar motor protein MotB -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68853.22 Da        Isoelectric Point: 9.6147

>NTDB_id=47004 HMPREF0462_RS02840 WP_000774354.1 567241..569025(-) (uvrC) [Helicobacter pylori 83]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHCASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGSHKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTYNEDLILEEARSLFKLECMPYRVEIFDA
SHHANGQCVGGMVVYENHEFQKNSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTSNDTFKLLPSDKRLQWMQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=47004 HMPREF0462_RS02840 WP_000774354.1 567241..569025(-) (uvrC) [Helicobacter pylori 83]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCTATCCGTAATAATGAAATCACGCCCA
ATCATTGCGCAAGCTTACGAATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAATGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAACAGCTCAAACCCAAATACAACATTCTTTTGAGAGACGATAAAACTTA
CCCTTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGTGGGGCTAAGGACATTTTAGACAGCTTATATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTGAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGATAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATAGTGGGAGCCATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTCAACGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTAATGCCAGAACAGATTTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAATTTATCTCTCATCAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTATA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGATGCA
AGCCACCATGCCAACGGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGAATTTCAAAAAAACTCCTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGTGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGTGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCACACCTCTAACGATACTTTTAAATTGCTCCCTAGCGACAAGCGCTTGCAGTGGATGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAGCAAATCGCTCTTTTAAAGGAAAAGGGTATA
GGAGAAGCTAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAACAAGAAAAAAA
CGCTGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB F4D5B5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.633

100

0.966

Multiple sequence alignment