Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HPIN_RS02440 Genome accession   NC_017372
Coordinates   496084..497868 (-) Length   594 a.a.
NCBI ID   WP_000774381.1    Uniprot ID   E8QFI6
Organism   Helicobacter pylori India7     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 491084..502868
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HPIN_RS02410 (HPIN_02460) - 491671..491919 (+) 249 WP_000790557.1 RNA-binding protein -
  HPIN_RS02415 (HPIN_02465) - 492125..492946 (-) 822 WP_001263463.1 glycosyltransferase family 25 protein -
  HPIN_RS02420 (HPIN_02470) trxB 493114..494049 (-) 936 WP_000564426.1 thioredoxin-disulfide reductase -
  HPIN_RS02425 (HPIN_02475) trxA 494054..494374 (-) 321 WP_000020204.1 thioredoxin -
  HPIN_RS02430 (HPIN_02480) - 494463..494807 (-) 345 WP_001211657.1 YraN family protein -
  HPIN_RS02435 (HPIN_02485) - 494808..496073 (-) 1266 WP_000746816.1 homoserine dehydrogenase -
  HPIN_RS02440 (HPIN_02490) uvrC 496084..497868 (-) 1785 WP_000774381.1 excinuclease ABC subunit UvrC Machinery gene
  HPIN_RS02445 (HPIN_02495) - 497869..498330 (-) 462 WP_000437222.1 hypothetical protein -
  HPIN_RS02450 (HPIN_02500) - 498322..498501 (+) 180 WP_000468793.1 hypothetical protein -
  HPIN_RS02455 (HPIN_02505) - 498513..499154 (-) 642 WP_000659344.1 ATP-binding cassette domain-containing protein -
  HPIN_RS02460 (HPIN_02510) - 499158..500819 (-) 1662 WP_001139670.1 ABC transporter permease/substrate-binding protein -
  HPIN_RS02465 (HPIN_02515) - 500889..501326 (-) 438 WP_014536097.1 hypothetical protein -
  HPIN_RS02470 (HPIN_02520) motB 501332..502105 (-) 774 WP_001085323.1 flagellar motor protein MotB -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68644.88 Da        Isoelectric Point: 9.7128

>NTDB_id=46960 HPIN_RS02440 WP_000774381.1 496084..497868(-) (uvrC) [Helicobacter pylori India7]
MADLLSSLKNLSNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIETAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDT
SHHANSQCVGGMVVYENNAFQKDSYRRYHLKGSDEYAQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRAKGGAKDIIHTSTNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=46960 HPIN_RS02440 WP_000774381.1 496084..497868(-) (uvrC) [Helicobacter pylori India7]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTAACAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
GCTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCCATCCGTAATAATGAAATCACGCCCA
ACCATCGCGCTAGCTTACGAATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTCACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAACAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTGGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATGGCGCAAGCAATAAGGCGGT
CTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAACCATTACCAATCGCATTTGCCTTTAATGCCAGAACAGATTTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAATTTATCTCTCATCAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAACCGCTATGAAAAACGCTCAAGAGATTTTTAGTCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTCAAATTAGAATGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAACGCATTTCAAAAAGACTCTTATCGGCG
CTACCATTTAAAAGGCTCTGATGAATACGCTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCGCTAAAGGGGGCGCTAAAGACATTAT
CCATACATCTACCAATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAGGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB E8QFI6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

98.148

100

0.981

Multiple sequence alignment