Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HPSA_RS03820 Genome accession   NC_017361
Coordinates   805263..807047 (+) Length   594 a.a.
NCBI ID   WP_000774372.1    Uniprot ID   E8QS22
Organism   Helicobacter pylori SouthAfrica7     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 800263..812047
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HPSA_RS03790 (HPSA_03940) motB 801030..801803 (+) 774 WP_001085289.1 flagellar motor protein MotB -
  HPSA_RS03795 (HPSA_03945) - 801809..802246 (+) 438 WP_000802459.1 hypothetical protein -
  HPSA_RS03800 (HPSA_03950) - 802316..803971 (+) 1656 WP_000901294.1 ABC transporter permease/substrate-binding protein -
  HPSA_RS03805 (HPSA_03955) - 803974..804624 (+) 651 WP_000391070.1 ATP-binding cassette domain-containing protein -
  HPSA_RS03810 (HPSA_03960) - 804630..804809 (-) 180 WP_001874585.1 hypothetical protein -
  HPSA_RS03815 (HPSA_03965) - 804801..805262 (+) 462 WP_000437229.1 hypothetical protein -
  HPSA_RS03820 (HPSA_03970) uvrC 805263..807047 (+) 1785 WP_000774372.1 excinuclease ABC subunit UvrC Machinery gene
  HPSA_RS03825 (HPSA_03975) - 807058..808323 (+) 1266 WP_000746725.1 homoserine dehydrogenase -
  HPSA_RS03830 (HPSA_03980) - 808324..808668 (+) 345 WP_001210425.1 YraN family protein -
  HPSA_RS03835 (HPSA_03985) trxA 808760..809080 (+) 321 WP_000020199.1 thioredoxin -
  HPSA_RS03840 (HPSA_03990) trxB 809086..810021 (+) 936 WP_000564447.1 thioredoxin-disulfide reductase -
  HPSA_RS03845 (HPSA_04000) - 810387..811208 (+) 822 WP_001263450.1 glycosyltransferase family 25 protein -
  HPSA_RS03850 (HPSA_04005) - 811427..811675 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68862.13 Da        Isoelectric Point: 9.6764

>NTDB_id=46817 HPSA_RS03820 WP_000774372.1 805263..807047(+) (uvrC) [Helicobacter pylori SouthAfrica7]
MADLLSSLKNLSNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDKLIKELQLKMDRLSSNLRFEEALIYRDRISKIQKI
APFTCMDLAKLYDLDIFAFYGKNNKAVLVKMFMRGGKIISSAFEKIHSLNEFDADEAMKQAIINHYQSHLPLMPEQILLS
ACSNETLKELQEFINHKHSKKIALNIPKKGDKLALIEIAMKNAQEIFSQEKTSNEEEILEEVRSLFNLECVPYRVEIFDT
SHHANSQCVGGMVVYENNAFQKNSYRRYHLKGLNEYTQMSELLTRRALDFIKEPPPNLWVIDGGRVQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKIKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRN

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=46817 HPSA_RS03820 WP_000774372.1 805263..807047(+) (uvrC) [Helicobacter pylori SouthAfrica7]
ATGGCTGATTTATTGTCCAGTTTAAAAAACCTTTCTAATAGCAGTGGGGTGTATCAATATTTTGATAAAAACCGCCAGTT
ACTCTACATCGGTAAAGCGAAAAACTTAAAAAAGCGCATCAAAAGCTATTTTTCTATCCATAATAATGAAATCACGCCCA
ACCATCGTGCAAGTTTGCGCATTCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACGATTTTAGTAGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAACAGCTCAAACCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACTAGCGGGGCTAAAGATATTTTGGATAGTTTGTATGAATTGCTCCCTTTAGTTCAAAAGAAA
AATTGCATTAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCTCCATGCGAGGATAAAATCACCAA
AGAAGAATATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAGCTCATCAAAGAACTTCAATTAA
AAATGGATCGCCTTTCTAGTAACTTGCGTTTTGAAGAAGCTCTAATCTATAGAGATAGGATTTCTAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATGGCAAAAACAACAAGGCGGT
GTTGGTGAAAATGTTCATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTCAACGAGTTTGACG
CTGATGAAGCGATGAAACAAGCGATCATTAACCATTACCAATCGCATTTGCCTTTAATGCCTGAACAAATTCTATTGAGC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAGTTTATCAATCATAAACACTCCAAAAAAATCGCTCTTAATATCCC
TAAAAAGGGCGATAAACTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCCA
ATGAAGAAGAAATTTTAGAAGAGGTGCGTTCGCTCTTCAATTTAGAGTGCGTGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAACGCATTCCAAAAAAACTCTTACCGGCG
CTACCATTTAAAAGGCTTGAATGAATACACTCAAATGAGTGAATTGCTCACTAGAAGGGCTTTAGATTTTATTAAAGAGC
CACCGCCTAATTTGTGGGTGATAGATGGAGGGAGGGTGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACCGATCCACTAAAATTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAAGAAAAAAA
CGCCGTTTTAAAAAAACGAAATTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB E8QS22

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

94.941

99.832

0.948

Multiple sequence alignment