Detailed information NTG0468154

Bioinformatically predicted

Overview

• Name: comGH
• Type: Machinery gene
• Locus tag: I6J38_RS06505
• Genome accession: NZ_CP069558
• Coordinates: 1316647..1317600 (-)
• Length: 317 a.a.
• NCBI ID: WP_020998065.1
• Uniprot ID: U2XY22
• Organism: Streptococcus constellatus strain FDAARGOS_1208
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1311647..1322600

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6J38_RS06495 (I6J38_06495)	glmS	1313196..1315010 (-)	1815	WP_020998064.1	glutamine--fructose-6-phosphate transaminase (isomerizing)	-
I6J38_RS06500 (I6J38_06500)	-	1315401..1316600 (-)	1200	WP_006267970.1	acetate kinase	-
I6J38_RS06505 (I6J38_06505)	comGH	1316647..1317600 (-)	954	WP_020998065.1	class I SAM-dependent methyltransferase	Machinery gene
I6J38_RS06510 (I6J38_06510)	comGG/cglG	1317685..1318011 (-)	327	WP_020998066.1	competence type IV pilus minor pilin ComGG	Machinery gene
I6J38_RS06515 (I6J38_06515)	comGF/cglF	1317992..1318429 (-)	438	WP_003035329.1	competence type IV pilus minor pilin ComGF	Machinery gene
I6J38_RS06520 (I6J38_06520)	comGE/cglE	1318413..1318706 (-)	294	WP_003035318.1	competence type IV pilus minor pilin ComGE	Machinery gene
I6J38_RS06525 (I6J38_06525)	comGD	1318678..1319106 (-)	429	WP_020999411.1	competence type IV pilus minor pilin ComGD	Machinery gene
I6J38_RS06530 (I6J38_06530)	comGC	1319066..1319383 (-)	318	WP_020998068.1	competence type IV pilus major pilin ComGC	Machinery gene
I6J38_RS06535 (I6J38_06535)	comGB	1319380..1320402 (-)	1023	WP_037592679.1	competence type IV pilus assembly protein ComGB	Machinery gene
I6J38_RS06540 (I6J38_06540)	comGA	1320344..1321285 (-)	942	WP_006268058.1	competence type IV pilus ATPase ComGA	Machinery gene
I6J38_RS06545 (I6J38_06545)	-	1321355..1321720 (-)	366	WP_022525692.1	DUF1033 family protein	-

Sequence

Protein

• Length: 317 a.a.
• Molecular weight: 35934.56 Da
• Isoelectric Point: 4.2141

>NTDB_id=468154 I6J38_RS06505 WP_020998065.1 1316647..1317600(-) (comGH) [Streptococcus constellatus strain FDAARGOS_1208]
MNFEKIEQAYSLLLENVQELQNTLLTNFYDALVEQNGVYLDGNTELDIVKKNNETLKSLKLDKEEWRRAYQFLLMKAAQT
EPLQANHQFTPDSIGFIVTFLIDQLSNKEHIDVLEIGSGMGNLAETILNNTNKNVDYLGLELDDLLIDISASIADVMDAK
VSFVQGDAVRPQVLKESDVIISDLPVGFYPDDNIATRYEVASRQEHTYAHHLLMEQSLKYLKSDGYAIFLAPNDLLTSTQ
SDLLKNWLQNHAQIVAMIALPESLFGNAAYAKTIFVLKKQDEQAVQPFVYALSDLQNQADLLTFSEKFQNWSQESEI

Nucleotide

• Length: 954 bp

>NTDB_id=468154 I6J38_RS06505 WP_020998065.1 1316647..1317600(-) (comGH) [Streptococcus constellatus strain FDAARGOS_1208]
ATGAATTTTGAAAAAATAGAACAGGCTTATTCGCTTTTGTTAGAAAATGTCCAGGAGCTCCAAAATACTCTTTTGACGAA
TTTTTATGATGCTTTGGTCGAGCAAAATGGGGTTTATCTGGATGGAAATACAGAGCTAGATATTGTCAAAAAAAATAATG
AAACACTTAAATCTTTGAAATTAGATAAAGAAGAATGGCGACGAGCATACCAATTTTTGCTGATGAAAGCGGCTCAAACA
GAGCCTTTGCAAGCTAATCATCAATTTACTCCGGATTCTATTGGTTTTATCGTAACATTTCTCATTGACCAATTGAGTAA
TAAAGAACATATTGATGTGTTGGAAATTGGTAGTGGAATGGGAAATTTGGCAGAAACCATTCTTAATAATACAAATAAAA
ACGTGGATTATCTAGGGCTGGAATTGGACGATCTGCTAATTGATATATCAGCCAGTATCGCAGATGTGATGGATGCAAAA
GTTAGTTTTGTGCAAGGTGATGCGGTGCGCCCGCAAGTATTGAAAGAAAGCGATGTGATTATCAGTGATTTACCAGTTGG
CTTTTATCCTGATGATAACATTGCGACGCGCTATGAAGTGGCTAGTAGACAGGAGCATACTTATGCTCATCATTTGTTAA
TGGAACAATCGCTCAAGTATCTCAAATCGGATGGTTATGCTATTTTCCTTGCACCAAATGATTTACTGACTAGCACACAA
AGTGATTTATTAAAAAATTGGTTGCAGAATCATGCACAAATAGTTGCAATGATTGCGTTACCAGAGTCTCTTTTTGGAAA
TGCAGCATACGCTAAAACAATTTTTGTACTGAAAAAGCAAGATGAACAAGCTGTCCAACCATTTGTTTATGCTTTATCTG
ATTTGCAGAATCAAGCGGATTTATTGACATTTAGCGAAAAGTTTCAAAATTGGAGCCAAGAAAGTGAAATTTAA

Domains

Predicted by InterProScan.

• N-6 DNA Methylase (N6_Mtase) (68-294)

3D structure

• AlphaFold DB: U2XY22

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGH	Streptococcus mutans UA140	61.587	99.369	0.612
comGH	Streptococcus mutans UA159	61.27	99.369	0.609