Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HMPREF4655_RS03745 Genome accession   NC_017360
Coordinates   751692..753476 (-) Length   594 a.a.
NCBI ID   WP_000774365.1    Uniprot ID   -
Organism   Helicobacter pylori 35A     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 746692..758476
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF4655_RS03715 (HMPREF4655_20768) - 747287..747535 (+) 249 WP_000790557.1 RNA-binding protein -
  HMPREF4655_RS03720 (HMPREF4655_20769) - 747732..748553 (-) 822 WP_001263429.1 glycosyltransferase family 25 protein -
  HMPREF4655_RS03725 (HMPREF4655_20770) trxB 748721..749656 (-) 936 WP_000564422.1 thioredoxin-disulfide reductase -
  HMPREF4655_RS03730 (HMPREF4655_20771) trxA 749662..749982 (-) 321 WP_000020200.1 thioredoxin -
  HMPREF4655_RS03735 (HMPREF4655_20772) - 750071..750415 (-) 345 WP_001211660.1 YraN family protein -
  HMPREF4655_RS03740 (HMPREF4655_20773) - 750416..751681 (-) 1266 WP_000746798.1 homoserine dehydrogenase -
  HMPREF4655_RS03745 (HMPREF4655_20774) uvrC 751692..753476 (-) 1785 WP_000774365.1 excinuclease ABC subunit UvrC Machinery gene
  HMPREF4655_RS03750 (HMPREF4655_20775) - 753477..753938 (-) 462 WP_000437196.1 hypothetical protein -
  HMPREF4655_RS03755 (HMPREF4655_20776) - 753930..754109 (+) 180 WP_000468796.1 hypothetical protein -
  HMPREF4655_RS03760 (HMPREF4655_20777) - 754121..754762 (-) 642 WP_000659345.1 ATP-binding cassette domain-containing protein -
  HMPREF4655_RS03765 (HMPREF4655_20778) - 754766..756322 (-) 1557 WP_000992669.1 ABC transporter permease/substrate-binding protein -
  HMPREF4655_RS03770 (HMPREF4655_20779) - 756386..756859 (-) 474 WP_001031793.1 hypothetical protein -
  HMPREF4655_RS03775 (HMPREF4655_20780) motB 756863..757630 (-) 768 WP_001085312.1 flagellar motor protein MotB -
  HMPREF4655_RS03780 (HMPREF4655_20781) motA 757633..758406 (-) 774 WP_000366176.1 flagellar motor stator protein MotA -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68773.95 Da        Isoelectric Point: 9.6559

>NTDB_id=46794 HMPREF4655_RS03745 WP_000774365.1 751692..753476(-) (uvrC) [Helicobacter pylori 35A]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSVRNNEITPNYRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYSKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGSNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
TCSNETLKELQDFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDT
SHHANSQCVGGMVVYENHEFQKNSYRHYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTANDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=46794 HMPREF4655_RS03745 WP_000774365.1 751692..753476(-) (uvrC) [Helicobacter pylori 35A]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTGTCCGCAATAATGAAATCACGCCCA
ATTATCGCGCAAGCTTACGAATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATCTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGATGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACCGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTCAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAACGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATAGTGGGAGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTCAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTAATGCCTGAACAAATCTTATTGAAC
ACTTGCTCTAATGAAACGCTTAAAGAATTGCAAGATTTTATCTCTCATCAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAGGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGAATTTCAAAAAAACTCCTATCGGCA
CTACCATTTAAAAGGCTCTAACGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTGCCAAAGAGC
CGCCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGAGGCGCTAAAGACATTAT
CCACACCGCTAACGATACTTTTAAATTACTCCCTAGCGACAAGCGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.801

100

0.968

Multiple sequence alignment