Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HPCU_RS04195 Genome accession   NC_017358
Coordinates   880087..881871 (+) Length   594 a.a.
NCBI ID   WP_000774338.1    Uniprot ID   A0AB32X8T6
Organism   Helicobacter pylori Cuz20     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 875087..886871
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HPCU_RS04165 (HPCU_04320) motB 875758..876525 (+) 768 WP_001085309.1 flagellar motor protein MotB -
  HPCU_RS04170 (HPCU_04325) - 876529..876966 (+) 438 WP_001031795.1 hypothetical protein -
  HPCU_RS04175 (HPCU_04330) - 877136..878797 (+) 1662 WP_014534262.1 ABC transporter permease/substrate-binding protein -
  HPCU_RS04180 (HPCU_04335) - 878801..879442 (+) 642 WP_000665993.1 ATP-binding cassette domain-containing protein -
  HPCU_RS04185 - 879454..879633 (-) 180 WP_000468794.1 hypothetical protein -
  HPCU_RS04190 (HPCU_04340) - 879625..880086 (+) 462 WP_000437219.1 hypothetical protein -
  HPCU_RS04195 (HPCU_04345) uvrC 880087..881871 (+) 1785 WP_000774338.1 excinuclease ABC subunit UvrC Machinery gene
  HPCU_RS04200 (HPCU_04350) - 881882..883147 (+) 1266 WP_000746815.1 homoserine dehydrogenase -
  HPCU_RS04205 (HPCU_04355) - 883148..883492 (+) 345 WP_001211674.1 YraN family protein -
  HPCU_RS04210 (HPCU_04360) trxA 883581..883901 (+) 321 WP_000020204.1 thioredoxin -
  HPCU_RS04215 (HPCU_04365) trxB 883907..884842 (+) 936 WP_000564369.1 thioredoxin-disulfide reductase -
  HPCU_RS04220 (HPCU_04370) - 885009..885830 (+) 822 WP_001263412.1 glycosyltransferase family 25 protein -
  HPCU_RS04225 (HPCU_04375) - 886031..886279 (-) 249 WP_000790556.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68850.19 Da        Isoelectric Point: 9.6558

>NTDB_id=46754 HPCU_RS04195 WP_000774338.1 880087..881871(+) (uvrC) [Helicobacter pylori Cuz20]
MADLLSSLKNLSHSSGVYQYFDKNCQLLYIGKAKNLKKRIKSYFSVRNNEITPNYRTSLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
SPFTCMDLAKLYDLDIFAFYGKGNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDT
SHHANSQCVGGMVVYENHEFQKNSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GESSVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=46754 HPCU_RS04195 WP_000774338.1 880087..881871(+) (uvrC) [Helicobacter pylori Cuz20]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACTGCCAATT
ACTCTATATTGGTAAGGCAAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTGTTCGTAATAATGAAATCACGCCCA
ATTATCGCACCAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAACAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAACCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
TCCCCCTTTACTTGCATGGATTTAGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATGGCAAGGGTAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGGAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCAGAACAGATTTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAATTTATCTCTCACCAATACTCTAAAAAAATCGCTCTTAGTATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGAATTTCAAAAAAACTCCTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTGCCAAAGAGC
CGCCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGTGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGAGGCGCTAAAGACATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAATCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.97

100

0.97

Multiple sequence alignment