Detailed information NTG0467434

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HTZ91_RS09885
• Genome accession: NZ_CP059155
• Coordinates: 2027427..2028470 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain WKZ-2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2022427..2033470

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HTZ91_RS09855 (HTZ91_001971)	-	2022848..2024104 (-)	1257	WP_001793983.1	aminopeptidase	-
HTZ91_RS09860 (HTZ91_001972)	-	2024107..2024307 (-)	201	WP_000180460.1	DUF1128 family protein	-
HTZ91_RS09865 (HTZ91_001973)	-	2024454..2024918 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
HTZ91_RS09870 (HTZ91_001974)	-	2024925..2025200 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
HTZ91_RS09875 (HTZ91_001975)	-	2025478..2026695 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
HTZ91_RS09880 (HTZ91_001976)	vraR	2026808..2027437 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
HTZ91_RS09885 (HTZ91_001977)	vraS	2027427..2028470 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HTZ91_RS09890 (HTZ91_001978)	liaF	2028467..2029168 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HTZ91_RS09895 (HTZ91_001979)	-	2029183..2029569 (-)	387	WP_001110178.1	hypothetical protein	-
HTZ91_RS09900 (HTZ91_001980)	map	2029786..2030544 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HTZ91_RS09910 (HTZ91_001982)	-	2031244..2032230 (+)	987	WP_001014423.1	aromatic acid exporter family protein	-
HTZ91_RS09915 (HTZ91_001983)	-	2032419..2032832 (-)	414	WP_001643743.1	hypothetical protein	-
HTZ91_RS09920 (HTZ91_001984)	-	2032861..2032971 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=467434 HTZ91_RS09885 WP_001017131.1 2027427..2028470(-) (vraS) [Staphylococcus aureus strain WKZ-2]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=467434 HTZ91_RS09885 WP_001017131.1 2027427..2028470(-) (vraS) [Staphylococcus aureus strain WKZ-2]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1