Detailed information NTG0466788

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: H0A38_RS11335
• Genome accession: NZ_CP059048
• Coordinates: 2306032..2307060 (-)
• Length: 342 a.a.
• NCBI ID: WP_003132657.1
• Uniprot ID: S6FVM6
• Organism: Lactococcus lactis strain LAC460
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2301032..2312060

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0A38_RS11305	-	2301078..2302004 (-)	927	WP_226319347.1	radical SAM protein	-
H0A38_RS11310 (H0A38_11245)	-	2302107..2302964 (-)	858	WP_129881184.1	transcriptional regulator	-
H0A38_RS11315 (H0A38_11250)	-	2303075..2304214 (-)	1140	WP_012898644.1	MFS transporter	-
H0A38_RS11320	-	2304211..2304501 (-)	291	WP_226319348.1	SPASM domain-containing protein	-
H0A38_RS11325 (H0A38_11255)	kwcM	2304420..2305529 (-)	1110	WP_226319349.1	KxxxW cyclic peptide radical SAM maturase	-
H0A38_RS11330 (H0A38_11260)	-	2305597..2305710 (-)	114	WP_011836076.1	KxxxW-cyclized peptide pheromone	-
H0A38_RS11335 (H0A38_11265)	sepM	2306032..2307060 (-)	1029	WP_003132657.1	SepM family pheromone-processing serine protease	Regulator
H0A38_RS11340 (H0A38_11270)	coaD	2307047..2307544 (-)	498	WP_010906348.1	pantetheine-phosphate adenylyltransferase	-
H0A38_RS11345 (H0A38_11275)	rsmD	2307592..2308131 (-)	540	WP_015427191.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
H0A38_RS11350 (H0A38_11280)	-	2308302..2309522 (-)	1221	WP_039116754.1	MFS transporter	-
H0A38_RS11355 (H0A38_11285)	lmrP	2309603..2310829 (-)	1227	WP_129881188.1	multidrug efflux MFS transporter LmrP	-

Sequence

Protein

• Length: 342 a.a.
• Molecular weight: 37349.96 Da
• Isoelectric Point: 9.9183

>NTDB_id=466788 H0A38_RS11335 WP_003132657.1 2306032..2307060(-) (sepM) [Lactococcus lactis strain LAC460]
MKKNKKINPKLKWGISIGLIVVALLALFYPTSYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYSH
FNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAIYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELADTITAV
NGQQFTSSADMIAYVSKQKVGDSVTIEYTRIDGTKHKSTGKYIKIANGKTGIGISLVDHTEVVTTPKVTVNAGSIGGPSA
GMMFTLEIYSQLTGKDLRNGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAKK
LKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1029 bp

>NTDB_id=466788 H0A38_RS11335 WP_003132657.1 2306032..2307060(-) (sepM) [Lactococcus lactis strain LAC460]
ATGAAAAAAAATAAAAAAATTAATCCCAAATTAAAATGGGGAATCTCGATTGGTCTAATTGTTGTTGCCCTTTTAGCTTT
ATTTTATCCAACGAGTTACTATGTGGAAATGCCCGGAACAACCGAGCCTTTAGGGAAAATGGTCAAAGTTGAAGGCAAAA
AAGATGAACATAAAGGTGATTTTTTTCTGACGACTGTCCAAATTGCACGAGCAAATCTTGCTACAATGATTTACAGCCAT
TTTAATAGTTTTACAAGCATTTACAGTGAGCAAGAAATGACTGGTGGACTTAACGACGCACAGTTCAACCGTGTCAACCA
GTTTTACATGGAAACGGCACAGAATACAGCGATTTATCAAGCTTTTAAATTAGCTAATAAACCTTATGAACTTAAATATG
AAGGCGTTTATGTCCTTGATATTGCCAAAAATTCGACCTTTAAAAATAAGCTAGAACTTGCAGATACGATTACAGCAGTC
AATGGTCAACAGTTTACATCAAGTGCCGACATGATTGCTTATGTTTCCAAACAAAAAGTCGGTGATTCAGTAACGATTGA
ATACACGAGAATTGACGGCACAAAGCACAAGTCAACTGGCAAATACATCAAAATTGCTAATGGAAAAACAGGAATTGGGA
TCAGCCTAGTTGACCATACTGAAGTCGTGACGACTCCAAAAGTTACTGTCAACGCGGGTTCAATCGGCGGTCCCTCTGCG
GGGATGATGTTTACACTAGAAATTTACAGTCAGTTGACAGGAAAAGATTTGCGAAACGGTCGCGAAATTGCTGGAACTGG
AACGATTGAACATGACGGAAGCATTGGCCAAATCGGCGGTGTTGATAAAAAAGTAGCCACAGCGAGCAAAGAAGGGGCAA
AGGTCTTCTTAGTGCCTGACTCAGGCACCAAAAAGGAAAGTAGCAACAATTACCTTGGAGCCAAAGCCGCAGCTAAAAAA
CTAAAAACGAAGATGAAAATCGTTCCCGTCAAAACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (134-194)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (227-338)

3D structure

• AlphaFold DB: S6FVM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.491