Detailed information NTG0466752

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: H0A38_RS02855
• Genome accession: NZ_CP059048
• Coordinates: 553710..556160 (+)
• Length: 816 a.a.
• NCBI ID: WP_226319374.1
• Uniprot ID: -
• Organism: Lactococcus lactis strain LAC460
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	531499..556852	553710..556160	within	0

Gene organization within MGE regions

Location: 531499..556852

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0A38_RS02705 (H0A38_02705)	-	531499..532395 (+)	897	WP_003129543.1	SPFH domain-containing protein	-
H0A38_RS02715	-	533079..533288 (-)	210	WP_226319367.1	hypothetical protein	-
H0A38_RS02720 (H0A38_02720)	-	534111..534698 (-)	588	WP_226319368.1	hypothetical protein	-
H0A38_RS02725 (H0A38_02725)	-	534709..535263 (-)	555	WP_058204350.1	helix-turn-helix domain-containing protein	-
H0A38_RS02730 (H0A38_02730)	-	535815..535985 (-)	171	WP_165379817.1	hypothetical protein	-
H0A38_RS02735 (H0A38_02735)	-	536051..536257 (+)	207	WP_058204351.1	helix-turn-helix transcriptional regulator	-
H0A38_RS02740 (H0A38_02740)	-	536312..537063 (+)	752	Protein_509	phage antirepressor KilAC domain-containing protein	-
H0A38_RS02745	-	537168..537353 (+)	186	WP_226319369.1	phage replisome organizer N-terminal domain-containing protein	-
H0A38_RS02750 (H0A38_02745)	-	537401..537988 (+)	588	WP_226319370.1	DnaD domain-containing protein	-
H0A38_RS02755	-	538196..538288 (+)	93	WP_081043124.1	DUF1660 family phage protein	-
H0A38_RS02760 (H0A38_02755)	-	538372..538761 (+)	390	WP_058204354.1	DUF722 domain-containing protein	-
H0A38_RS02765 (H0A38_02760)	-	539039..540196 (+)	1158	WP_058204355.1	glycoside hydrolase family protein	-
H0A38_RS02770	-	540440..540508 (+)	69	WP_235589974.1	terminase small subunit	-
H0A38_RS02775 (H0A38_02770)	-	541019..541240 (+)	222	WP_129881467.1	hemolysin XhlA family protein	-
H0A38_RS02780 (H0A38_02775)	-	541253..541528 (+)	276	WP_058204825.1	holin	-
H0A38_RS02785 (H0A38_02780)	-	541558..542307 (+)	750	WP_226319371.1	peptidoglycan amidohydrolase family protein	-
H0A38_RS02790 (H0A38_02785)	-	542416..543342 (+)	927	WP_226319372.1	peptidyl-prolyl cis-trans isomerase	-
H0A38_RS02795 (H0A38_02790)	-	543378..543650 (-)	273	WP_058204930.1	hypothetical protein	-
H0A38_RS11940	-	543781..543915 (+)	135	WP_257394348.1	hypothetical protein	-
H0A38_RS02805 (H0A38_02800)	-	544722..544982 (+)	261	WP_129881469.1	SemiSWEET family transporter	-
H0A38_RS02815 (H0A38_02810)	rnz	545339..546262 (+)	924	WP_003129545.1	ribonuclease Z	-
H0A38_RS02820 (H0A38_02815)	-	546255..546956 (+)	702	WP_226319373.1	SDR family oxidoreductase	-
H0A38_RS02825 (H0A38_02820)	recJ	547123..549351 (+)	2229	WP_058204929.1	single-stranded-DNA-specific exonuclease RecJ	-
H0A38_RS02830 (H0A38_02825)	-	549474..549986 (+)	513	WP_012897343.1	adenine phosphoribosyltransferase	-
H0A38_RS02835 (H0A38_02830)	rpoE	550203..550766 (+)	564	WP_012897344.1	DNA-directed RNA polymerase subunit delta	-
H0A38_RS02840 (H0A38_02835)	mltG	550903..552555 (+)	1653	WP_058203216.1	endolytic transglycosylase MltG	-
H0A38_RS02845 (H0A38_02840)	greA	552615..553088 (+)	474	WP_033899645.1	transcription elongation factor GreA	-
H0A38_RS02850 (H0A38_02845)	-	553265..553720 (+)	456	WP_010905471.1	CtsR family transcriptional regulator	-
H0A38_RS02855 (H0A38_02850)	clpC	553710..556160 (+)	2451	WP_226319374.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
H0A38_RS02860 (H0A38_02855)	hpf	556295..556852 (+)	558	WP_003129564.1	ribosome hibernation-promoting factor, HPF/YfiA family	-

Sequence

Protein

• Length: 816 a.a.
• Molecular weight: 90483.90 Da
• Isoelectric Point: 6.5300

>NTDB_id=466752 H0A38_RS02855 WP_226319374.1 553710..556160(+) (clpC) [Lactococcus lactis strain LAC460]
MKFENIKYTPTLDRILEKAEEYAHQYQYGTIESAHLLAAMATTSGSIAYSLLTGMNVDSSDLLIDLEDLSSHVKVKRSTL
RFSPRAEEVMTAASFLAIHNNSEAVGTEHLLYALLQVEDGFGLQLLKLQKINIVSLRKELEKRTGLKVPESKKAVTPMSK
RKMAKGVAENSTTPTLDSVSSDLTEEARLGKLDPMIGREAEIDRLIHILSRRTKNNPVLVGEPGVGKSAIIEGLAQRIVN
GQVPIGLMNSRIMALNMATVVAGTKFRGEFEDRLTAIVEEVSSDPDVIIFIDELHTIIGAGGGMDSVNDAANILKPALAR
GDFQMVGATTYHEYQKYIEKDEALERRLARINVDEPSPDEAIAILQGLREKFEDYHQVKFTDQAIKSAVMLSVRYMTSRK
LPDKAIDLLDEAAAAVKISVKNQQTKRLDLEKELVEAQEELSEAVIKLDIKASRTKEKAVEKIADKIYKFSVKEDKRQEV
TDQAVVAVASTLTGVPITQMTKSESDRLINLEKELHKRVVGQEEAISAVSRAIRRARSGVADSRRPMGSFMFLGPTGVGK
TELAKALADSVFGSEDNMIRVDMSEFMEKHSTSRLIGAPPGYVGYDEGGQLTERVRNKPYSVVLLDEVEKAHPDVFNIML
QILDDGFVTDTKGRKVDFRNTIIIMTSNLGATALRDDKTVGFGAKNITADYSAMKSRILEELKRHYRPEFLNRIDENIVF
HSLESQEIEQIVKIMSKSLIKRLAEQDIHVKLTPSAVKLIAEVGFDPEYGARPLRKALQKEVEDLLSEQLLSGEIKAGNH
VSIGASNKKIKIAQIV

Nucleotide

• Length: 2451 bp

>NTDB_id=466752 H0A38_RS02855 WP_226319374.1 553710..556160(+) (clpC) [Lactococcus lactis strain LAC460]
ATGAAATTTGAAAATATAAAATATACACCAACGCTTGACCGAATTTTAGAAAAAGCGGAAGAGTATGCTCACCAATATCA
ATATGGCACCATTGAAAGTGCTCATTTACTAGCTGCAATGGCAACGACCTCAGGCTCAATTGCTTACAGCCTCCTTACTG
GAATGAATGTTGATTCTTCTGACTTACTGATTGATTTAGAGGATTTATCAAGTCATGTTAAGGTCAAACGTTCAACTTTA
CGTTTTTCACCTCGTGCAGAAGAAGTGATGACTGCGGCAAGTTTTTTAGCAATTCATAATAACTCAGAAGCCGTTGGAAC
AGAACACCTGCTTTATGCCCTACTTCAAGTAGAAGATGGATTTGGTCTTCAACTTCTAAAATTACAAAAAATCAATATTG
TATCTTTGCGAAAAGAGCTTGAGAAAAGAACTGGACTCAAAGTTCCAGAAAGTAAAAAAGCTGTGACTCCAATGTCAAAA
CGTAAGATGGCAAAGGGAGTTGCAGAAAATTCAACGACGCCAACGTTAGACTCTGTATCCTCAGATTTAACCGAAGAAGC
TCGCTTGGGTAAACTTGATCCAATGATTGGACGAGAAGCTGAAATTGACCGTTTGATTCATATTCTCAGCCGCAGAACAA
AAAATAATCCTGTCTTAGTTGGAGAGCCCGGTGTTGGGAAATCAGCAATTATTGAAGGTTTGGCCCAAAGAATTGTCAAT
GGTCAAGTTCCAATTGGTTTGATGAATAGTCGAATTATGGCCTTGAATATGGCGACTGTTGTTGCTGGGACAAAATTTAG
AGGTGAATTTGAGGATCGTTTGACAGCTATTGTTGAAGAAGTTAGCAGTGATCCAGATGTCATTATTTTCATTGATGAAT
TACACACAATCATCGGTGCTGGTGGCGGTATGGATTCTGTCAATGATGCCGCAAATATTTTGAAACCAGCGCTTGCTCGT
GGTGATTTTCAAATGGTCGGAGCAACAACCTATCATGAATATCAAAAATATATTGAAAAAGATGAAGCTTTAGAACGCCG
TTTGGCGAGAATAAATGTTGATGAGCCAAGTCCAGATGAAGCGATTGCTATCTTGCAAGGCTTACGTGAAAAATTTGAAG
ACTATCATCAAGTGAAATTTACTGACCAAGCCATTAAAAGTGCTGTAATGCTCAGTGTTCGTTATATGACTAGCCGAAAA
TTGCCTGACAAAGCCATTGATTTACTTGATGAAGCTGCAGCAGCAGTGAAAATTTCTGTCAAAAATCAACAAACAAAACG
TCTTGATTTAGAAAAAGAATTAGTGGAAGCTCAAGAAGAATTATCAGAAGCTGTCATTAAACTTGATATCAAAGCGTCTC
GTACAAAAGAAAAAGCAGTTGAAAAAATTGCTGACAAGATTTATAAATTCTCAGTAAAAGAAGATAAACGTCAAGAAGTT
ACTGACCAAGCTGTTGTTGCTGTTGCCTCAACACTGACAGGTGTTCCAATCACACAAATGACTAAGTCTGAAAGTGATCG
TTTAATCAATCTTGAAAAAGAATTACATAAACGAGTTGTTGGACAAGAAGAAGCTATTTCTGCCGTTTCAAGAGCCATTC
GTCGGGCACGTTCCGGTGTTGCTGACAGCCGCCGTCCAATGGGTTCTTTCATGTTCCTTGGACCAACAGGGGTTGGTAAA
ACCGAACTTGCTAAAGCACTGGCTGACAGTGTGTTTGGTAGTGAAGATAATATGATTCGTGTTGACATGAGTGAATTCAT
GGAAAAACATTCGACTTCACGCTTGATTGGAGCTCCTCCAGGGTATGTAGGTTATGATGAGGGTGGTCAATTGACAGAAC
GCGTTCGTAATAAACCTTATTCTGTTGTTCTTTTAGATGAAGTCGAAAAAGCTCATCCTGACGTTTTCAACATCATGTTG
CAAATTCTAGATGATGGCTTTGTGACTGATACTAAAGGTCGTAAAGTTGATTTCAGAAATACAATTATTATCATGACTTC
AAACTTGGGAGCGACTGCTCTTCGTGATGATAAGACAGTTGGTTTTGGCGCTAAAAATATCACAGCTGATTATTCAGCCA
TGAAATCAAGAATATTAGAAGAGCTTAAACGTCATTATCGTCCTGAGTTTCTTAATCGAATTGATGAAAATATTGTTTTC
CACTCATTGGAAAGTCAAGAGATTGAACAAATTGTTAAAATTATGAGTAAATCTTTGATTAAACGTCTGGCAGAACAAGA
TATTCATGTTAAACTCACACCGTCAGCGGTGAAATTAATTGCTGAGGTAGGTTTTGACCCAGAATATGGTGCACGTCCGC
TCCGCAAGGCTCTTCAAAAAGAAGTTGAAGACCTTTTAAGTGAACAATTGCTCTCTGGTGAAATCAAAGCAGGTAATCAT
GTTTCAATTGGTGCATCTAATAAAAAAATTAAAATCGCTCAAATTGTTTGA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (723-802)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (19-69)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (96-144)

• AAA lid domain (AAA_lid_9) (357-453)

• ATPase family associated with various cellular activities (AAA) (AAA) (218-334)

• AAA domain (Cdc48 subfamily) (AAA_2) (545-716)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	99.755	100	0.998
clpC	Streptococcus thermophilus LMD-9	50.662	100	0.516
clpC	Streptococcus thermophilus LMG 18311	50.542	100	0.515
clpC	Streptococcus pneumoniae Rx1	48.798	100	0.498
clpC	Streptococcus pneumoniae D39	48.798	100	0.498
clpC	Bacillus subtilis subsp. subtilis str. 168	50.499	98.284	0.496
clpC	Streptococcus pneumoniae TIGR4	48.678	100	0.496
clpC	Streptococcus mutans UA159	48.317	100	0.493
clpE	Streptococcus mutans UA159	47.846	79.657	0.381
clpC	Lactococcus lactis subsp. cremoris KW2	46.87	80.27	0.376
clpE	Streptococcus pneumoniae TIGR4	47.687	76.838	0.366
clpE	Streptococcus pneumoniae Rx1	47.687	76.838	0.366
clpE	Streptococcus pneumoniae D39	47.687	76.838	0.366
clpE	Streptococcus pneumoniae R6	47.687	76.838	0.366