Detailed information NTG0046660

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MS7_RS10260
• Genome accession: NC_017351
• Coordinates: 2013224..2014267 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus 11819-97
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2008224..2019267

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MS7_RS10230 (MS7_1914)	-	2008646..2009902 (-)	1257	WP_001793428.1	aminopeptidase	-
MS7_RS10235 (MS7_1915)	-	2009905..2010105 (-)	201	WP_000180463.1	DUF1128 family protein	-
MS7_RS10240 (MS7_1916)	-	2010252..2010716 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MS7_RS10245 (MS7_1917)	-	2010723..2010998 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MS7_RS10250 (MS7_1918)	-	2011276..2012493 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
MS7_RS10255 (MS7_1919)	vraR	2012605..2013234 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MS7_RS10260 (MS7_1920)	vraS	2013224..2014267 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MS7_RS10265 (MS7_1921)	liaF	2014264..2014965 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MS7_RS10270 (MS7_1922)	-	2014980..2015366 (-)	387	WP_001110179.1	hypothetical protein	-
MS7_RS10275 (MS7_1923)	map	2015583..2016341 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MS7_RS10290 (MS7_1924)	-	2016931..2017917 (+)	987	WP_000999718.1	aromatic acid exporter family protein	-
MS7_RS10300 (MS7_1925)	-	2018407..2018820 (-)	414	WP_001837236.1	hypothetical protein	-
MS7_RS10305	-	2018849..2018960 (-)	112	Protein_1941	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=46660 MS7_RS10260 WP_001017131.1 2013224..2014267(-) (vraS) [Staphylococcus aureus subsp. aureus 11819-97]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=46660 MS7_RS10260 WP_001017131.1 2013224..2014267(-) (vraS) [Staphylococcus aureus subsp. aureus 11819-97]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1