Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   MS7_RS00465 Genome accession   NC_017351
Coordinates   74773..76122 (-) Length   449 a.a.
NCBI ID   WP_000815640.1    Uniprot ID   -
Organism   Staphylococcus aureus subsp. aureus 11819-97     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 39686..81293 74773..76122 within 0


Gene organization within MGE regions


Location: 39686..81293
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MS7_RS00280 (MS7_0033) mecA 39686..41695 (-) 2010 WP_063852655.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  MS7_RS00285 (MS7_0034) - 41792..42778 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  MS7_RS00290 (MS7_0035) - 42750..43010 (+) 261 WP_001549961.1 type I restriction enzyme endonuclease domain-containing protein -
  MS7_RS00295 (MS7_0036) - 43001..44608 (-) 1608 Protein_33 IS1182 family transposase -
  MS7_RS00300 (MS7_0037) - 44660..45166 (-) 507 WP_001092189.1 DUF1643 domain-containing protein -
  MS7_RS00305 (MS7_0038) - 45181..45492 (-) 312 WP_000700851.1 DUF960 family protein -
  MS7_RS00310 (MS7_0039) - 45579..45929 (-) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  MS7_RS00315 (MS7_0040) - 46346..47161 (-) 816 WP_000164963.1 AAA family ATPase -
  MS7_RS00320 (MS7_0041) - 47154..48596 (-) 1443 WP_000790705.1 Mu transposase C-terminal domain-containing protein -
  MS7_RS00325 (MS7_0042) - 48568..49161 (-) 594 WP_000690628.1 recombinase family protein -
  MS7_RS00330 (MS7_0043) blaI 49425..49805 (-) 381 WP_001284656.1 penicillinase repressor BlaI -
  MS7_RS00335 (MS7_0044) blaR1 49795..51552 (-) 1758 WP_001096386.1 beta-lactam sensor/signal transducer BlaR1 -
  MS7_RS00340 (MS7_0045) blaZ 51659..52504 (+) 846 WP_000733273.1 penicillin-hydrolyzing class A beta-lactamase BlaZ -
  MS7_RS00345 (MS7_0046) - 53170..54069 (-) 900 WP_000196697.1 Mph(C) family macrolide 2'-phosphotransferase -
  MS7_RS00350 (MS7_0047) msr(A) 54168..55634 (-) 1467 WP_000438874.1 ABC-F type ribosomal protection protein Msr(A) -
  MS7_RS00355 (MS7_0048) - 56108..56782 (+) 675 WP_001105960.1 IS6 family transposase -
  MS7_RS15560 (MS7_0049) - 57076..57249 (-) 174 WP_000044738.1 hypothetical protein -
  MS7_RS00360 (MS7_0050) - 57293..57913 (-) 621 WP_000941203.1 LysE family transporter -
  MS7_RS00365 (MS7_0051) - 57918..58889 (-) 972 WP_000053810.1 fatty acid desaturase family protein -
  MS7_RS00370 (MS7_0052) - 58988..60400 (+) 1413 WP_000526300.1 PLP-dependent aminotransferase family protein -
  MS7_RS00375 (MS7_0053) - 60592..61266 (+) 675 WP_001105960.1 IS6 family transposase -
  MS7_RS00380 (MS7_0054) braR 61406..62080 (+) 675 WP_000866106.1 response regulator transcription factor Regulator
  MS7_RS00390 (MS7_0056) - 62077..62958 (+) 882 Protein_52 sensor histidine kinase -
  MS7_RS00395 (MS7_0057) - 63074..64003 (+) 930 WP_000793446.1 ABC transporter ATP-binding protein -
  MS7_RS00400 (MS7_0058) - 63996..64733 (+) 738 WP_000369394.1 ABC transporter permease -
  MS7_RS00405 (MS7_0059) - 64747..64923 (+) 177 Protein_55 undecaprenyl-diphosphate phosphatase -
  MS7_RS00410 (MS7_0060) - 64980..65654 (+) 675 WP_001105960.1 IS6 family transposase -
  MS7_RS00415 (MS7_0061) - 65795..66430 (+) 636 Protein_57 aminoglycoside 6-adenylyltransferase -
  MS7_RS00420 (MS7_0062) sat4 66427..66957 (+) 531 WP_000627289.1 streptothricin N-acetyltransferase Sat4 -
  MS7_RS00425 (MS7_0063) aph(3')-IIIa 67050..67844 (+) 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
  MS7_RS15605 - 68120..68251 (+) 132 Protein_60 HTH domain-containing protein -
  MS7_RS15610 - 68327..69072 (+) 746 Protein_61 WYL domain-containing protein -
  MS7_RS00440 (MS7_0065) - 69183..69842 (+) 660 WP_000802831.1 RibD family protein -
  MS7_RS14695 - 70563..72167 (-) 1605 Protein_63 IS1182-like element IS1182 family transposase -
  MS7_RS00455 (MS7_0068) - 72326..72757 (+) 432 Protein_64 hypothetical protein -
  MS7_RS15350 - 72758..72841 (+) 84 Protein_65 ATP-binding protein -
  MS7_RS00460 (MS7_0069) ccrB 73123..74751 (-) 1629 WP_001186608.1 recombinase family protein Machinery gene
  MS7_RS00465 (MS7_0070) ccrA 74773..76122 (-) 1350 WP_000815640.1 recombinase family protein Machinery gene
  MS7_RS00470 (MS7_0071) - 76356..78149 (-) 1794 WP_000079473.1 DUF927 domain-containing protein -
  MS7_RS00475 (MS7_0072) - 78149..78445 (-) 297 WP_000273823.1 single-stranded DNA-binding protein -
  MS7_RS00480 (MS7_0073) - 78638..79684 (-) 1047 WP_001042023.1 hypothetical protein -
  MS7_RS00485 (MS7_0074) - 80139..81293 (+) 1155 WP_000912116.1 ATP-binding protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52663.34 Da        Isoelectric Point: 9.9639

>NTDB_id=46626 MS7_RS00465 WP_000815640.1 74773..76122(-) (ccrA) [Staphylococcus aureus subsp. aureus 11819-97]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=46626 MS7_RS00465 WP_000815640.1 74773..76122(-) (ccrA) [Staphylococcus aureus subsp. aureus 11819-97]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Recombinase (Recombinase)

(169-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

97.55

100

0.976
  ccrA Staphylococcus aureus COL

75.947

100

0.759

Multiple sequence alignment