Detailed information NTG0046538

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: SAT0131_RS00260
• Genome accession: NC_017347
• Coordinates: 59254..60600 (-)
• Length: 448 a.a.
• NCBI ID: WP_000816499.1
• Uniprot ID: Q9R3W9
• Organism: Staphylococcus aureus subsp. aureus T0131
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	39530..60600	59254..60600	within	0

Gene organization within MGE regions

Location: 39530..60600

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAT0131_RS00160 (SAT0131_00034)	mecA	39530..41539 (-)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
SAT0131_RS00165 (SAT0131_00035)	mecR1	41636..43393 (+)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
SAT0131_RS00170	mecI	43393..43764 (+)	372	Protein_32	mecA-type methicillin resistance repressor MecI	-
SAT0131_RS15665	psm-mec	43849..43917 (-)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
SAT0131_RS00175 (SAT0131_00037)	-	44237..45385 (+)	1149	WP_000427807.1	ROK family transcriptional regulator	-
SAT0131_RS00185 (SAT0131_00039)	cstB	45499..46833 (-)	1335	Protein_35	persulfide dioxygenase-sulfurtransferase CstB	-
SAT0131_RS00190 (SAT0131_00040)	-	46866..47930 (-)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
SAT0131_RS00195 (SAT0131_00041)	cstR	48066..48326 (+)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
SAT0131_RS00200 (SAT0131_00042)	-	48326..48964 (+)	639	Protein_38	sulfite exporter TauE/SafE family protein	-
SAT0131_RS00205 (SAT0131_00044)	-	49238..49855 (-)	618	WP_000562107.1	CadD family cadmium resistance transporter	-
SAT0131_RS00210 (SAT0131_00046)	-	49936..52350 (-)	2415	WP_000378485.1	cadmium-translocating P-type ATPase CadA	-
SAT0131_RS00215 (SAT0131_00047)	-	52343..52708 (-)	366	WP_000159127.1	metalloregulator ArsR/SmtB family transcription factor	-
SAT0131_RS00220 (SAT0131_00048)	-	52946..53323 (-)	378	WP_000361060.1	DUF6262 family protein	-
SAT0131_RS00225 (SAT0131_00049)	-	53330..55222 (-)	1893	WP_014533070.1	site-specific integrase	-
SAT0131_RS00230 (SAT0131_00050)	-	55418..55741 (-)	324	WP_000088091.1	JAB domain-containing protein	-
SAT0131_RS00235 (SAT0131_00051)	-	55734..55940 (-)	207	WP_001077283.1	hypothetical protein	-
SAT0131_RS00240 (SAT0131_00053)	-	55942..56463 (-)	522	WP_000836008.1	DUF1643 domain-containing protein	-
SAT0131_RS00245 (SAT0131_00054)	-	56482..56793 (-)	312	WP_000833212.1	DUF960 family protein	-
SAT0131_RS00250	-	56796..57134 (-)	339	WP_000171448.1	SAUGI family uracil-DNA glycosylase inhibitor	-
SAT0131_RS00255 (SAT0131_00055)	ccrB	57605..59233 (-)	1629	WP_001186596.1	recombinase family protein	Machinery gene
SAT0131_RS00260 (SAT0131_00056)	ccrA	59254..60600 (-)	1347	WP_000816499.1	recombinase family protein	Machinery gene

Sequence

Protein

• Length: 448 a.a.
• Molecular weight: 52138.19 Da
• Isoelectric Point: 10.1760

>NTDB_id=46538 SAT0131_RS00260 WP_000816499.1 59254..60600(-) (ccrA) [Staphylococcus aureus subsp. aureus T0131]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA

Nucleotide

• Length: 1347 bp

>NTDB_id=46538 SAT0131_RS00260 WP_000816499.1 59254..60600(-) (ccrA) [Staphylococcus aureus subsp. aureus T0131]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (168-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-321)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9R3W9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus COL	78.174	100	0.783
ccrA	Staphylococcus aureus N315	72.383	100	0.725