Detailed information NTG0464583

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HZR12_RS04740
• Genome accession: NZ_CP058615
• Coordinates: 943734..944777 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 110900
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 938734..949777

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HZR12_RS04710 (HZR12_04710)	-	939104..939214 (+)	111	WP_001790257.1	hypothetical protein	-
HZR12_RS04715 (HZR12_04715)	-	939243..939656 (+)	414	WP_001549145.1	hypothetical protein	-
HZR12_RS04720 (HZR12_04720)	-	940087..941073 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
HZR12_RS04725 (HZR12_04725)	map	941660..942418 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HZR12_RS04730 (HZR12_04730)	-	942635..943021 (+)	387	WP_001110179.1	hypothetical protein	-
HZR12_RS04735 (HZR12_04735)	liaF	943036..943737 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HZR12_RS04740 (HZR12_04740)	vraS	943734..944777 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HZR12_RS04745 (HZR12_04745)	vraR	944767..945396 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
HZR12_RS04750 (HZR12_04750)	-	945512..946729 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
HZR12_RS04755 (HZR12_04755)	-	947007..947282 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
HZR12_RS04760 (HZR12_04760)	-	947289..947753 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HZR12_RS04765 (HZR12_04765)	-	947900..948100 (+)	201	WP_000180461.1	DUF1128 family protein	-
HZR12_RS04770 (HZR12_04770)	-	948103..949359 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=464583 HZR12_RS04740 WP_001017131.1 943734..944777(+) (vraS) [Staphylococcus aureus strain 110900]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=464583 HZR12_RS04740 WP_001017131.1 943734..944777(+) (vraS) [Staphylococcus aureus strain 110900]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1