Detailed information
Bioinformatically predicted
Overview
| Name | agrA | Type | Regulator |
| Locus tag | HZR12_RS04220 | Genome accession | NZ_CP058615 |
| Coordinates | 848489..849205 (-) | Length | 238 a.a. |
| NCBI ID | WP_000688492.1 | Uniprot ID | A0A7U7IEW1 |
| Organism | Staphylococcus aureus strain 110900 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 848489..885270 | 848489..849205 | within | 0 |
Gene organization within MGE regions
Location: 848489..885270
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZR12_RS04220 (HZR12_04220) | agrA | 848489..849205 (-) | 717 | WP_000688492.1 | quorum-sensing response regulator AgrA | Regulator |
| HZR12_RS04225 (HZR12_04225) | agrC | 849224..850516 (-) | 1293 | WP_001554031.1 | quorum-sensing sensor histidine kinase AgrC | - |
| HZR12_RS04230 (HZR12_04230) | agrD | 850541..850681 (-) | 141 | WP_001093929.1 | cyclic lactone autoinducer peptide AgrD | - |
| HZR12_RS04235 (HZR12_04235) | agrB | 850678..851247 (-) | 570 | WP_001105707.1 | accessory gene regulator AgrB | - |
| HZR12_RS14945 | hld | 851537..851617 (+) | 81 | WP_000046022.1 | delta-hemolysin | - |
| HZR12_RS04255 (HZR12_04255) | - | 854051..854836 (-) | 786 | WP_000867960.1 | carbon-nitrogen family hydrolase | - |
| HZR12_RS04260 (HZR12_04260) | - | 855197..855823 (-) | 627 | WP_000522384.1 | nitroreductase family protein | - |
| HZR12_RS04265 (HZR12_04265) | - | 856020..857129 (+) | 1110 | WP_181665314.1 | SdrH family protein | - |
| HZR12_RS04270 (HZR12_04270) | mroQ | 857154..857897 (-) | 744 | WP_000197635.1 | CPBP family intramembrane glutamic endopeptidase MroQ | - |
| HZR12_RS04275 (HZR12_04275) | groES | 858072..858356 (+) | 285 | WP_000917289.1 | co-chaperone GroES | - |
| HZR12_RS04280 (HZR12_04280) | groL | 858432..860048 (+) | 1617 | WP_000240645.1 | chaperonin GroEL | - |
| HZR12_RS04285 (HZR12_04285) | - | 860117..861289 (-) | 1173 | WP_000179353.1 | tyrosine-type recombinase/integrase | - |
| HZR12_RS04290 (HZR12_04290) | - | 861303..862025 (-) | 723 | WP_000672427.1 | helix-turn-helix domain-containing protein | - |
| HZR12_RS04295 (HZR12_04295) | - | 862178..862384 (+) | 207 | WP_000794657.1 | helix-turn-helix transcriptional regulator | - |
| HZR12_RS04300 (HZR12_04300) | - | 862388..862705 (+) | 318 | WP_000481968.1 | helix-turn-helix domain-containing protein | - |
| HZR12_RS04305 (HZR12_04305) | - | 862702..862848 (+) | 147 | WP_000708434.1 | hypothetical protein | - |
| HZR12_RS04310 (HZR12_04310) | tscA | 862841..863050 (+) | 210 | WP_001058487.1 | type II toxin-antitoxin system antitoxin TscA | - |
| HZR12_RS04315 (HZR12_04315) | tscT | 863053..863370 (+) | 318 | WP_001103933.1 | type II toxin-antitoxin system toxin TscT | - |
| HZR12_RS04320 (HZR12_04320) | - | 863437..864306 (+) | 870 | WP_001002699.1 | primase alpha helix C-terminal domain-containing protein | - |
| HZR12_RS04325 (HZR12_04325) | - | 864323..865792 (+) | 1470 | WP_001838755.1 | virulence-associated E family protein | - |
| HZR12_RS04330 (HZR12_04330) | - | 866078..866440 (+) | 363 | WP_001039169.1 | hypothetical protein | - |
| HZR12_RS04335 (HZR12_04335) | - | 866442..866726 (+) | 285 | WP_000998179.1 | hypothetical protein | - |
| HZR12_RS04340 (HZR12_04340) | - | 866723..867364 (+) | 642 | WP_001019811.1 | hypothetical protein | - |
| HZR12_RS04345 (HZR12_04345) | - | 867899..868240 (+) | 342 | WP_001190614.1 | hypothetical protein | - |
| HZR12_RS04350 (HZR12_04350) | - | 868271..868924 (+) | 654 | WP_029625649.1 | hypothetical protein | - |
| HZR12_RS04355 (HZR12_04355) | - | 868977..869504 (+) | 528 | WP_000771371.1 | spore coat protein | - |
| HZR12_RS04360 (HZR12_04360) | - | 869636..869848 (+) | 213 | WP_078065371.1 | pathogenicity island family protein | - |
| HZR12_RS04365 (HZR12_04365) | - | 869845..870414 (+) | 570 | WP_001293084.1 | terminase small subunit | - |
| HZR12_RS04370 (HZR12_04370) | - | 870801..871814 (+) | 1014 | WP_029625650.1 | DUF6731 family protein | - |
| HZR12_RS04375 (HZR12_04375) | - | 871827..872294 (+) | 468 | WP_029625651.1 | hypothetical protein | - |
| HZR12_RS04380 (HZR12_04380) | - | 872547..872759 (+) | 213 | WP_031875240.1 | hypothetical protein | - |
| HZR12_RS14775 | - | 872831..872947 (+) | 117 | Protein_856 | hypothetical protein | - |
| HZR12_RS04385 (HZR12_04385) | - | 873311..874225 (+) | 915 | WP_029625652.1 | iron-hydroxamate ABC transporter substrate-binding protein | - |
| HZR12_RS04390 (HZR12_04390) | - | 874283..875131 (+) | 849 | WP_000824908.1 | class I SAM-dependent methyltransferase | - |
| HZR12_RS04395 (HZR12_04395) | - | 876025..877332 (-) | 1308 | WP_001045079.1 | TrkH family potassium uptake protein | - |
| HZR12_RS04400 (HZR12_04400) | - | 877493..878404 (+) | 912 | WP_000825510.1 | iron-hydroxamate ABC transporter substrate-binding protein | - |
| HZR12_RS04405 (HZR12_04405) | - | 878466..879310 (+) | 845 | Protein_861 | class I SAM-dependent methyltransferase | - |
| HZR12_RS04420 (HZR12_04420) | - | 881519..882742 (-) | 1224 | WP_000206638.1 | ArgE/DapE family deacylase | - |
| HZR12_RS04425 (HZR12_04425) | lukH | 883177..884232 (+) | 1056 | WP_048665762.1 | bi-component leukocidin LukGH subunit H | - |
| HZR12_RS04430 (HZR12_04430) | lukG | 884254..885270 (+) | 1017 | WP_000595324.1 | bi-component leukocidin LukGH subunit G | - |
Sequence
Protein
Download Length: 238 a.a. Molecular weight: 27905.90 Da Isoelectric Point: 6.0927
>NTDB_id=464582 HZR12_RS04220 WP_000688492.1 848489..849205(-) (agrA) [Staphylococcus aureus strain 110900]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI
Nucleotide
Download Length: 717 bp
>NTDB_id=464582 HZR12_RS04220 WP_000688492.1 848489..849205(-) (agrA) [Staphylococcus aureus strain 110900]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACCTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCTGAATTAAGAACTCGAATTATAGACTGTTTAGAAACTGCACATACACGCTTACAATTGT
TGTCTAAAGATAATAGCGTTGAAACGATTGAATTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCTCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTTAGATGTCATAATAGCTTTGTCGTCAATCGCCATAATATTGAATCTATAG
ATTCGAAAGAGCGAATTGTCTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACCTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCTGAATTAAGAACTCGAATTATAGACTGTTTAGAAACTGCACATACACGCTTACAATTGT
TGTCTAAAGATAATAGCGTTGAAACGATTGAATTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCTCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTTAGATGTCATAATAGCTTTGTCGTCAATCGCCATAATATTGAATCTATAG
ATTCGAAAGAGCGAATTGTCTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| agrA | Staphylococcus aureus N315 |
100 |
100 |
1 |