Detailed information NTG0464568

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HZR13_RS09810
• Genome accession: NZ_CP058613
• Coordinates: 1961263..1962306 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 128254
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1956263..1967306

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HZR13_RS09780 (HZR13_09780)	-	1956681..1957937 (-)	1257	WP_001795438.1	aminopeptidase	-
HZR13_RS09785 (HZR13_09785)	-	1957940..1958140 (-)	201	WP_000180461.1	DUF1128 family protein	-
HZR13_RS09790 (HZR13_09790)	-	1958287..1958751 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HZR13_RS09795 (HZR13_09795)	-	1958758..1959033 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
HZR13_RS09800 (HZR13_09800)	-	1959311..1960528 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
HZR13_RS09805 (HZR13_09805)	vraR	1960644..1961273 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
HZR13_RS09810 (HZR13_09810)	vraS	1961263..1962306 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HZR13_RS09815 (HZR13_09815)	liaF	1962303..1963004 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HZR13_RS09820 (HZR13_09820)	-	1963019..1963405 (-)	387	WP_001110179.1	hypothetical protein	-
HZR13_RS09825 (HZR13_09825)	map	1963622..1964380 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HZR13_RS09830 (HZR13_09830)	-	1964967..1965953 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
HZR13_RS09835 (HZR13_09835)	-	1966384..1966797 (-)	414	WP_001549145.1	hypothetical protein	-
HZR13_RS09840 (HZR13_09840)	-	1966826..1966936 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=464568 HZR13_RS09810 WP_001017131.1 1961263..1962306(-) (vraS) [Staphylococcus aureus strain 128254]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=464568 HZR13_RS09810 WP_001017131.1 1961263..1962306(-) (vraS) [Staphylococcus aureus strain 128254]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1