Detailed information NTG0046410

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: SAA6008_RS00300
• Genome accession: NC_017341
• Coordinates: 64953..66299 (-)
• Length: 448 a.a.
• NCBI ID: WP_000816499.1
• Uniprot ID: Q9R3W9
• Organism: Staphylococcus aureus subsp. aureus str. JKD6008
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	45140..66299	64953..66299	within	0

Gene organization within MGE regions

Location: 45140..66299

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAA6008_RS00200 (SAA6008_00039)	mecA	45140..47149 (-)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
SAA6008_RS00205 (SAA6008_00040)	mecR1	47246..49003 (+)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
SAA6008_RS00210 (SAA6008_00041)	mecI	49003..49374 (+)	372	WP_000369216.1	mecA-type methicillin resistance repressor MecI	-
SAA6008_RS15955	psm-mec	49459..49527 (-)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
SAA6008_RS00215 (SAA6008_00042)	-	49861..50991 (+)	1131	WP_010922808.1	ROK family transcriptional regulator	-
SAA6008_RS00225 (SAA6008_00044)	cstB	51105..52439 (-)	1335	Protein_41	persulfide dioxygenase-sulfurtransferase CstB	-
SAA6008_RS00230 (SAA6008_00045)	-	52472..53536 (-)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
SAA6008_RS00235 (SAA6008_00046)	cstR	53672..53932 (+)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
SAA6008_RS00240 (SAA6008_00047)	-	53932..54570 (+)	639	Protein_44	sulfite exporter TauE/SafE family protein	-
SAA6008_RS00245 (SAA6008_00048)	-	54844..55461 (-)	618	WP_000562107.1	CadD family cadmium resistance transporter	-
SAA6008_RS00250 (SAA6008_00049)	-	55542..57956 (-)	2415	WP_000378487.1	cadmium-translocating P-type ATPase CadA	-
SAA6008_RS00255 (SAA6008_00050)	-	57949..58314 (-)	366	WP_000159127.1	metalloregulator ArsR/SmtB family transcription factor	-
SAA6008_RS00260 (SAA6008_00051)	-	58552..58929 (-)	378	WP_001041908.1	DUF6262 family protein	-
SAA6008_RS00265 (SAA6008_00052)	-	58936..60828 (-)	1893	WP_002485298.1	site-specific integrase	-
SAA6008_RS00270 (SAA6008_00053)	-	61023..61346 (-)	324	WP_000088091.1	JAB domain-containing protein	-
SAA6008_RS00275 (SAA6008_00054)	-	61339..61545 (-)	207	WP_001077283.1	hypothetical protein	-
SAA6008_RS00280 (SAA6008_00055)	-	61547..62068 (-)	522	WP_000836008.1	DUF1643 domain-containing protein	-
SAA6008_RS00285 (SAA6008_00056)	-	62087..62398 (-)	312	WP_000833212.1	DUF960 family protein	-
SAA6008_RS00290 (SAA6008_9980)	-	62483..62833 (-)	351	WP_000171449.1	SAUGI family uracil-DNA glycosylase inhibitor	-
SAA6008_RS00295 (SAA6008_00057)	ccrB	63304..64932 (-)	1629	WP_001186596.1	recombinase family protein	Machinery gene
SAA6008_RS00300 (SAA6008_00058)	ccrA	64953..66299 (-)	1347	WP_000816499.1	recombinase family protein	Machinery gene

Sequence

Protein

• Length: 448 a.a.
• Molecular weight: 52138.19 Da
• Isoelectric Point: 10.1760

>NTDB_id=46410 SAA6008_RS00300 WP_000816499.1 64953..66299(-) (ccrA) [Staphylococcus aureus subsp. aureus str. JKD6008]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA

Nucleotide

• Length: 1347 bp

>NTDB_id=46410 SAA6008_RS00300 WP_000816499.1 64953..66299(-) (ccrA) [Staphylococcus aureus subsp. aureus str. JKD6008]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (168-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-321)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9R3W9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus COL	78.174	100	0.783
ccrA	Staphylococcus aureus N315	72.383	100	0.725