Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | SA2981_RS00290 | Genome accession | NC_017340 |
| Coordinates | 64050..65399 (-) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus 04-02981 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 57179..100904 | 64050..65399 | within | 0 |
| SCCmec | 44034..65399 | 64050..65399 | within | 0 |
Gene organization within MGE regions
Location: 44034..100904
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SA2981_RS00190 (SA2981_0039) | mecA | 44034..46043 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| SA2981_RS00195 (SA2981_0040) | mecR1 | 46140..47897 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| SA2981_RS00200 (SA2981_0041) | mecI | 47897..48268 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| SA2981_RS14980 | psm-mec | 48353..48421 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| SA2981_RS00205 (SA2981_0043) | - | 48755..49885 (+) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| SA2981_RS00215 (SA2981_0044) | cstB | 49999..51333 (-) | 1335 | Protein_39 | persulfide dioxygenase-sulfurtransferase CstB | - |
| SA2981_RS00220 (SA2981_0046) | - | 51366..52430 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| SA2981_RS00225 (SA2981_0047) | cstR | 52566..52826 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| SA2981_RS00230 (SA2981_0048) | - | 52826..53464 (+) | 639 | Protein_42 | sulfite exporter TauE/SafE family protein | - |
| SA2981_RS00235 (SA2981_0050) | - | 53809..54471 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| SA2981_RS00240 (SA2981_0052) | erm(A) | 55005..55736 (+) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| SA2981_RS00245 (SA2981_0053) | - | 55862..56644 (-) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| SA2981_RS00250 (SA2981_0054) | - | 56795..57172 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| SA2981_RS00255 (SA2981_0055) | - | 57179..59071 (-) | 1893 | WP_001557544.1 | site-specific integrase | - |
| SA2981_RS00260 (SA2981_0056) | - | 59068..60153 (-) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| SA2981_RS00265 (SA2981_0057) | - | 60272..60589 (-) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| SA2981_RS00270 (SA2981_0058) | - | 60610..61116 (-) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| SA2981_RS00275 (SA2981_0059) | - | 61134..61445 (-) | 312 | WP_000700853.1 | DUF960 family protein | - |
| SA2981_RS00280 (SA2981_0060) | - | 61532..61882 (-) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| SA2981_RS00285 (SA2981_0061) | ccrB | 62400..64028 (-) | 1629 | WP_001186602.1 | recombinase family protein | Machinery gene |
| SA2981_RS00290 (SA2981_0062) | ccrA | 64050..65399 (-) | 1350 | WP_000815646.1 | recombinase family protein | Machinery gene |
| SA2981_RS00295 (SA2981_0063) | - | 65633..67426 (-) | 1794 | WP_000195105.1 | DUF927 domain-containing protein | - |
| SA2981_RS00300 (SA2981_0064) | - | 67426..67722 (-) | 297 | WP_000273824.1 | single-stranded DNA-binding protein | - |
| SA2981_RS00305 (SA2981_0065) | - | 67915..68961 (-) | 1047 | WP_001060127.1 | hypothetical protein | - |
| SA2981_RS14390 | - | 69212..70353 (-) | 1142 | Protein_58 | IS3-like element ISSau4 family transposase | - |
| SA2981_RS15290 | - | 70523..70657 (+) | 135 | WP_001792216.1 | hypothetical protein | - |
| SA2981_RS00325 | - | 70864..71790 (-) | 927 | Protein_60 | YfcC family protein | - |
| SA2981_RS00330 (SA2981_0070) | - | 72512..73207 (-) | 696 | WP_000858967.1 | response regulator transcription factor | - |
| SA2981_RS00335 (SA2981_0071) | - | 73182..75851 (-) | 2670 | WP_000446429.1 | sensor histidine kinase KdpD | - |
| SA2981_RS00340 | kdpF | 76018..76098 (+) | 81 | WP_000631574.1 | K(+)-transporting ATPase subunit F | - |
| SA2981_RS00345 (SA2981_0072) | kdpA | 76119..77795 (+) | 1677 | WP_000029431.1 | potassium-transporting ATPase subunit KdpA | - |
| SA2981_RS00350 (SA2981_0073) | - | 77814..79835 (+) | 2022 | WP_000852430.1 | K(+)-transporting ATPase subunit B | - |
| SA2981_RS00355 (SA2981_0074) | - | 79851..80409 (+) | 559 | Protein_66 | K(+)-transporting ATPase subunit C | - |
| SA2981_RS00360 (SA2981_0075) | - | 80953..81822 (-) | 870 | WP_000626133.1 | hypothetical protein | - |
| SA2981_RS00365 (SA2981_0076) | - | 81832..82728 (-) | 897 | WP_000411461.1 | DUF927 domain-containing protein | - |
| SA2981_RS00375 (SA2981_0080) | - | 83847..84473 (-) | 627 | WP_001176969.1 | hypothetical protein | - |
| SA2981_RS00380 (SA2981_0081) | - | 84588..86096 (+) | 1509 | WP_001001347.1 | protein kinase | - |
| SA2981_RS00385 | - | 86346..86480 (-) | 135 | WP_001790628.1 | hypothetical protein | - |
| SA2981_RS00390 | - | 86444..86536 (+) | 93 | WP_001790000.1 | hypothetical protein | - |
| SA2981_RS00395 (SA2981_0082) | - | 86683..88428 (+) | 1746 | WP_000700190.1 | DUF6119 family protein | - |
| SA2981_RS00400 (SA2981_0083) | - | 88526..88881 (-) | 356 | Protein_74 | tRNA-dihydrouridine synthase | - |
| SA2981_RS00405 | - | 89186..89274 (-) | 89 | Protein_75 | hypothetical protein | - |
| SA2981_RS00410 (SA2981_0084) | - | 89372..90127 (-) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| SA2981_RS00415 (SA2981_0085) | cstR | 90127..90387 (-) | 261 | WP_001105088.1 | persulfide-sensing transcriptional repressor CstR | - |
| SA2981_RS00420 (SA2981_0086) | cstA | 90524..91588 (+) | 1065 | WP_000816133.1 | persulfide response sulfurtransferase CstA | - |
| SA2981_RS00425 (SA2981_0087) | cstB | 91619..92953 (+) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| SA2981_RS00430 (SA2981_0088) | sqr | 92972..94165 (+) | 1194 | WP_001033018.1 | type II sulfide:quinone oxidoreductase Sqr | - |
| SA2981_RS15325 | - | 94432..94646 (-) | 215 | Protein_81 | universal stress protein | - |
| SA2981_RS00440 (SA2981_0089) | - | 94832..95818 (-) | 987 | WP_000662022.1 | tRNA-dihydrouridine synthase | - |
| SA2981_RS00445 (SA2981_0090) | - | 96127..96330 (+) | 204 | WP_000389759.1 | DUF6007 family protein | - |
| SA2981_RS00450 (SA2981_0091) | - | 96379..96675 (+) | 297 | WP_000201644.1 | TfoX/Sxy family protein | - |
| SA2981_RS00455 (SA2981_0092) | - | 96883..97485 (+) | 603 | WP_000908956.1 | hypothetical protein | - |
| SA2981_RS00460 (SA2981_0093) | - | 97752..100904 (+) | 3153 | WP_000080564.1 | DEAD/DEAH box helicase | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=46366 SA2981_RS00290 WP_000815646.1 64050..65399(-) (ccrA) [Staphylococcus aureus 04-02981]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=46366 SA2981_RS00290 WP_000815646.1 64050..65399(-) (ccrA) [Staphylococcus aureus 04-02981]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |