Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HWU11_RS03960 Genome accession   NZ_CP058285
Coordinates   840209..841993 (+) Length   594 a.a.
NCBI ID   WP_237008034.1    Uniprot ID   -
Organism   Helicobacter pylori strain BT302     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 835209..846993
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HWU11_RS03925 - 835261..835608 (+) 348 Protein_778 osmoprotection protein -
  HWU11_RS03930 - 835622..836194 (-) 573 WP_237008030.1 Hpy99I family type II restriction endonuclease -
  HWU11_RS03935 - 836188..837006 (-) 819 WP_237008031.1 DNA-methyltransferase -
  HWU11_RS03940 - 837257..838918 (+) 1662 WP_237008938.1 ABC transporter permease/substrate-binding protein -
  HWU11_RS03945 - 838922..839563 (+) 642 WP_237008032.1 ATP-binding cassette domain-containing protein -
  HWU11_RS03950 - 839575..839754 (-) 180 WP_000468793.1 hypothetical protein -
  HWU11_RS03955 - 839746..840201 (+) 456 WP_237008033.1 hypothetical protein -
  HWU11_RS03960 uvrC 840209..841993 (+) 1785 WP_237008034.1 excinuclease ABC subunit UvrC Machinery gene
  HWU11_RS03965 - 842004..843269 (+) 1266 WP_237008035.1 homoserine dehydrogenase -
  HWU11_RS03970 - 843269..843613 (+) 345 WP_237008036.1 YraN family protein -
  HWU11_RS03975 trxA 843702..844022 (+) 321 WP_000020204.1 thioredoxin -
  HWU11_RS03980 trxB 844028..844963 (+) 936 WP_000564425.1 thioredoxin-disulfide reductase -
  HWU11_RS03985 - 845320..846141 (+) 822 WP_237008037.1 glycosyltransferase family 25 protein -
  HWU11_RS03990 - 846354..846602 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68655.77 Da        Isoelectric Point: 9.6256

>NTDB_id=463455 HWU11_RS03960 WP_237008034.1 840209..841993(+) (uvrC) [Helicobacter pylori strain BT302]
MADLLSSLKNLSNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMTENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGGSNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQDFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFELECMPYRVEIFDT
SHHANSQCVGGMVVYENHAFQKDSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRN

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=463455 HWU11_RS03960 WP_237008034.1 840209..841993(+) (uvrC) [Helicobacter pylori strain BT302]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTAACAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCCATCCGTAATAATGAAATCACGCCCA
ACCATCGCGCAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCCTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACATA
CCCTTACATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTGGACAGCTTGTATGAGTTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAACAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGACTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATGGTGGGAGTAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCTGCGTTTGAAAAAATCCACTCTCTCAACGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAACCATTACCAATCGCATTTGCCTTTGATGCCAGAACAGATTTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGATTTTATCTCCCATCAATACTCTAAAAAAATCGCTCTTAGTATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTGAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGCATTCCAAAAAGACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAACTGCTCACCAGAAGGGCTTTAGATTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATCTTAAAAAGCAGCGGGAGT
TTTGTGGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCTGTTTTGAAAAAACGAAATTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.976

99.832

0.978