Detailed information NTG0463257

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: HW271_RS07990
• Genome accession: NZ_CP058258
• Coordinates: 1629326..1631758 (-)
• Length: 810 a.a.
• NCBI ID: WP_178895547.1
• Uniprot ID: A0A7H8ZAP2
• Organism: Streptococcus sp. oral taxon 061 strain F0704
• Function: degradation of ComW (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1627054..1628402	1629326..1631758	flank	924

Gene organization within MGE regions

Location: 1627054..1631758

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HW271_RS07985 (HW271_07985)	-	1628477..1629250 (-)	774	WP_178895546.1	NUDIX hydrolase	-
HW271_RS07990 (HW271_07990)	clpC	1629326..1631758 (-)	2433	WP_178895547.1	ATP-dependent Clp protease ATP-binding subunit	Regulator

Sequence

Protein

• Length: 810 a.a.
• Molecular weight: 90199.18 Da
• Isoelectric Point: 6.1235

>NTDB_id=463257 HW271_RS07990 WP_178895547.1 1629326..1631758(-) (clpC) [Streptococcus sp. oral taxon 061 strain F0704]
MEYSKALRECIDSAFLVASRFGADYLESWHLLIAMANHSYSVAGATLNEFPYEIDRLEEVAVELTEANFNHKEDYKELPF
SYRLNVLMLEAEHVASVVHAKALGTEHLLYAILHDGNALATRILEKAGFSYEDQKDQVKIAGLRRSLEARAGWTKEDLKA
LRQRHRSVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDQEISRMIQILSRKTKNNPVLVGDAGVGK
TALALGLAQRIASGDVPVEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVMIEEPSVADSMAILQGLKATYEKHHHVQITDDAVET
AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKSKHVKSDESGLTAADKALMDGKWKQAAQLISKEQVTPVYKDVVKESDI
LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIEQEQAVSSISRAIRRNQSGIRNNKRPIGSFMFLGPTGVGKTELAK
ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD
GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKTYRPEFINRIDEKVVFHSLSS
QDMQEVVKIMVKPLIASLAEKGIDLKLQASALKLLAQQGYDPEMGARPLRRTLQTEVEDKLAELLLTGELKEGKTLKIGV
KAGQLKFDIV

Nucleotide

• Length: 2433 bp

>NTDB_id=463257 HW271_RS07990 WP_178895547.1 1629326..1631758(-) (clpC) [Streptococcus sp. oral taxon 061 strain F0704]
ATGGAATATTCAAAAGCATTGAGAGAATGTATAGACAGTGCCTTTCTAGTGGCGAGTCGCTTTGGAGCAGACTACCTGGA
GTCTTGGCACCTACTGATTGCTATGGCTAATCATAGCTACAGTGTTGCTGGAGCAACTTTGAACGAGTTTCCATATGAAA
TTGATCGTTTAGAGGAGGTAGCTGTTGAATTAACAGAGGCAAACTTTAACCACAAGGAAGATTACAAGGAACTCCCTTTT
TCCTATCGTTTAAACGTCTTGATGTTGGAGGCGGAACATGTTGCCTCCGTTGTACATGCAAAAGCATTGGGAACTGAGCA
CCTTCTCTACGCAATCTTGCATGACGGCAATGCTTTAGCTACTCGCATTTTGGAAAAAGCAGGATTTTCTTATGAAGACC
AGAAGGACCAAGTCAAGATTGCTGGACTTCGTCGTAGCCTTGAAGCGCGTGCTGGTTGGACAAAGGAAGATTTGAAGGCT
CTACGTCAGCGCCATCGCTCAGTAGCAGATAAGCAAAACTCCATGGCTAATATGATGGGCATGCCTCAAACTCCAAGTGG
TGGTTTGGAAGATTACACTCATGATCTCACAGAGCAAGCTCGTTCAGGCAAATTGGAGCCAGTTATCGGACGTGATCAAG
AAATCTCTCGTATGATTCAAATTTTGAGCCGGAAGACAAAGAATAATCCTGTACTAGTTGGTGACGCAGGTGTTGGTAAA
ACAGCTCTAGCACTTGGACTAGCTCAGCGAATTGCTAGTGGAGATGTACCGGTTGAAATGGCTAAGATGCGAGTCTTAGA
ACTCGATTTGATGAATGTGGTTGCAGGGACACGTTTCCGTGGTGATTTTGAAGAGCGCATGAACAACATCATTAAAGACA
TTGAGGAAGATGGTCAGGTTATTCTCTTTATAGATGAGCTCCATACCATCATGGGTTCAGGGAGCGGGATTGATTCGACC
TTGGATGCAGCCAATATCTTGAAGCCAGCCTTGGCGCGTGGAACTTTGAGAACGGTTGGTGCCACCACTCAGGAAGAATA
CCAAAAACACATCGAAAAAGACGCAGCCCTTTCTCGTCGCTTTGCAAAAGTGATGATTGAGGAGCCGAGCGTGGCTGACA
GTATGGCTATCTTACAGGGCTTGAAAGCAACTTATGAGAAGCACCACCATGTCCAAATTACAGACGATGCTGTAGAAACA
GCTGTTAAAATGGCGCATCGCTATTTGACAAGCCGTCACTTGCCAGACTCAGCGATTGACCTTTTGGATGAAGCAGCAGC
GACAGTCCAAAACAAATCGAAACATGTGAAATCAGATGAGTCAGGTTTAACAGCAGCTGACAAGGCCTTGATGGATGGCA
AATGGAAGCAAGCAGCGCAGCTCATTTCAAAAGAGCAGGTAACCCCTGTTTACAAAGATGTCGTAAAAGAATCTGATATT
TTGACAACCTTGAGTCGCTTGTCAGGCATTCCAGTTCAAAAATTGACGCAAACAGATGCTAAGAAGTATCTCAATCTTGA
AGCTGAACTCCACAAGCGTGTGATTGAGCAAGAACAAGCAGTATCTAGTATCAGTCGTGCCATTCGCCGAAATCAATCAG
GTATTCGCAATAACAAACGTCCAATTGGATCCTTTATGTTCTTAGGACCAACTGGTGTTGGTAAAACTGAATTGGCTAAG
GCTTTGGCAGAAGTCCTCTTTGATGACGAATCTGCCCTTATCCGCTTTGATATGAGTGAGTACATGGAGAAATTTGCAGC
TAGCCGTCTCAACGGAGCTCCTCCAGGTTATGTAGGCTATGAAGAAGGTGGAGAGTTGACTGAGAAGGTCCGCAATAAAC
CATATTCAGTCTTGCTTTTTGACGAGGTAGAAAAGGCTCACCCAGATATCTTTAATGTTCTCTTGCAGGTCTTAGATGAT
GGTGTCTTGACGGACAGTAAAGGCCGTAAGGTTGATTTTTCAAATACCATCATTATCATGACGTCGAACCTTGGTGCGAC
AGCTCTTCGTGATGACAAGACAGTCGGTTTTGGAGCTAAGGATATTCGTTTTGATCAGGAAAATATGGAAAAACGAATGT
TTGAAGAGTTGAAAAAGACATATCGTCCAGAGTTCATCAACCGTATTGATGAAAAAGTGGTCTTCCATAGCTTGTCAAGT
CAAGATATGCAGGAAGTGGTTAAGATTATGGTCAAACCACTGATTGCAAGCCTGGCAGAAAAAGGAATTGACTTGAAACT
CCAAGCATCTGCCCTGAAGCTTCTAGCTCAGCAAGGCTATGATCCAGAGATGGGGGCTCGTCCACTGCGCAGAACTCTGC
AAACAGAAGTAGAAGACAAACTAGCAGAACTCCTTCTTACAGGTGAACTGAAAGAAGGTAAGACACTGAAGATTGGCGTC
AAAGCTGGTCAATTGAAGTTTGACATTGTATAA

Domains

Predicted by InterproScan.

• Clp amino terminal domain, pathogenicity island component (Clp_N) (14-60)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (103-137)

• ATPase family associated with various cellular activities (AAA) (AAA) (231-364)

• AAA domain (Cdc48 subfamily) (AAA_2) (540-711)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (718-798)

• AAA lid domain (AAA_lid_9) (370-445)

3D structure

• AlphaFold DB: A0A7H8ZAP2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus pneumoniae Rx1	91.347	99.877	0.912
clpC	Streptococcus pneumoniae D39	91.347	99.877	0.912
clpC	Streptococcus pneumoniae TIGR4	91.347	99.877	0.912
clpC	Streptococcus mutans UA159	67.69	100	0.68
clpC	Streptococcus thermophilus LMD-9	66.135	100	0.665
clpC	Streptococcus thermophilus LMG 18311	66.012	100	0.664
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	50.181	100	0.515
clpC	Bacillus subtilis subsp. subtilis str. 168	44.581	100	0.447
clpE	Streptococcus mutans UA159	47.634	78.272	0.373