Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HWU18_RS02690 Genome accession   NZ_CP058252
Coordinates   578629..580413 (+) Length   594 a.a.
NCBI ID   WP_237004645.1    Uniprot ID   -
Organism   Helicobacter pylori strain NP05-124     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 573629..585413
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HWU18_RS02660 motB 574393..575166 (+) 774 WP_120853369.1 flagellar motor protein MotB -
  HWU18_RS02665 - 575172..575609 (+) 438 WP_014536745.1 hypothetical protein -
  HWU18_RS02670 - 575678..577339 (+) 1662 WP_237004643.1 ABC transporter permease/substrate-binding protein -
  HWU18_RS02675 - 577343..577984 (+) 642 WP_237004644.1 ATP-binding cassette domain-containing protein -
  HWU18_RS02680 - 577996..578175 (-) 180 WP_039082895.1 hypothetical protein -
  HWU18_RS02685 - 578167..578628 (+) 462 WP_000437184.1 hypothetical protein -
  HWU18_RS02690 uvrC 578629..580413 (+) 1785 WP_237004645.1 excinuclease ABC subunit UvrC Machinery gene
  HWU18_RS02695 - 580424..581689 (+) 1266 WP_237004646.1 homoserine dehydrogenase -
  HWU18_RS02700 - 581690..582034 (+) 345 WP_001211689.1 YraN family protein -
  HWU18_RS02705 trxA 582123..582443 (+) 321 WP_000020204.1 thioredoxin -
  HWU18_RS02710 trxB 582449..583384 (+) 936 WP_000564419.1 thioredoxin-disulfide reductase -
  HWU18_RS02715 - 583744..584565 (+) 822 WP_050839930.1 glycosyltransferase family 25 protein -
  HWU18_RS02720 - 584762..585010 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68674.89 Da        Isoelectric Point: 9.7159

>NTDB_id=463072 HWU18_RS02690 WP_237004645.1 578629..580413(+) (uvrC) [Helicobacter pylori strain NP05-124]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASDQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=463072 HWU18_RS02690 WP_237004645.1 578629..580413(+) (uvrC) [Helicobacter pylori strain NP05-124]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
GCTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCCATCCGCAATAATGAAATCACGCCCA
ACCATCGCGCAAGTTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACGATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGCAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCCAATAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGACATTTTTGCTTTTTATGGCGCGAGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGGTTTGACA
CTGATGAGGCGATGAAACAAGCCATTATCAACCATTACCAATCGCATTTGCCTTTGATGCCTGAACAAATTCTATTAAAC
GCTTGTTCTAATGAAGCGCTTAAAGAATTGCAAGAGTTTATCTCTCATCAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAGGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTTTTCAATTTAGAGTGCGTGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAATGCATTCCAAAAAAACTCTTACCGGCG
CTACCATTTAAAAGGCTCTAACGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTAATAGATGGAGGGAGAGTGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTGGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGATCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

98.316

100

0.983