Detailed information NTG0046266

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SAPIG_RS10365
• Genome accession: NC_017333
• Coordinates: 2052871..2053914 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus ST398
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2047871..2058914

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAPIG_RS10335 (SAPIG1972)	-	2048292..2049548 (-)	1257	WP_074347694.1	aminopeptidase	-
SAPIG_RS10340 (SAPIG1973)	-	2049551..2049751 (-)	201	WP_000180460.1	DUF1128 family protein	-
SAPIG_RS10345 (SAPIG1974)	-	2049898..2050362 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SAPIG_RS10350 (SAPIG1975)	-	2050369..2050644 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SAPIG_RS10355 (SAPIG1976)	-	2050922..2052139 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
SAPIG_RS10360 (SAPIG1977)	vraR	2052252..2052881 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SAPIG_RS10365 (SAPIG1978)	vraS	2052871..2053914 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SAPIG_RS10370 (SAPIG1979)	liaF	2053911..2054612 (-)	702	WP_000149063.1	cell wall-active antibiotics response protein LiaF	-
SAPIG_RS10375 (SAPIG1980)	-	2054627..2055013 (-)	387	WP_001110182.1	hypothetical protein	-
SAPIG_RS10380 (SAPIG1981)	map	2055230..2055988 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
SAPIG_RS10395 (SAPIG1982)	-	2056572..2057558 (+)	987	WP_000999712.1	FUSC family protein	-
SAPIG_RS10400 (SAPIG1983)	-	2057747..2058160 (-)	414	WP_025174370.1	hypothetical protein	-
SAPIG_RS10405	-	2058189..2058299 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=46266 SAPIG_RS10365 WP_001017131.1 2052871..2053914(-) (vraS) [Staphylococcus aureus subsp. aureus ST398]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=46266 SAPIG_RS10365 WP_001017131.1 2052871..2053914(-) (vraS) [Staphylococcus aureus subsp. aureus ST398]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1