Detailed information NTG0449484

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STT128_RS07795
• Genome accession: NZ_CP065500
• Coordinates: 1510784..1511569 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain ST128
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1505784..1516569

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STT128_RS07760 (STT128_07845)	gatC	1505846..1506148 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STT128_RS07765 (STT128_07850)	-	1506288..1506542 (-)	255	WP_024010053.1	glycosyl transferase	-
STT128_RS07770 (STT128_07855)	-	1506555..1506764 (-)	210	WP_080998437.1	glycosyltransferase	-
STT128_RS07775 (STT128_07860)	-	1507080..1508524 (-)	1445	Protein_1478	6-phospho-beta-glucosidase	-
STT128_RS07780 (STT128_07865)	msrA	1508677..1509186 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STT128_RS07785 (STT128_07870)	-	1509198..1510046 (-)	849	WP_014608646.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STT128_RS07790 (STT128_07875)	-	1510170..1510721 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
STT128_RS07795 (STT128_07880)	codY	1510784..1511569 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STT128_RS07800 (STT128_07885)	-	1511829..1513043 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
STT128_RS07805 (STT128_07890)	-	1513398..1513850 (+)	453	WP_002946987.1	universal stress protein	-
STT128_RS07810 (STT128_07895)	-	1514030..1514601 (+)	572	Protein_1485	IS30 family transposase	-
STT128_RS07815 (STT128_07900)	-	1514673..1514846 (-)	174	WP_011681546.1	hypothetical protein	-
STT128_RS07820 (STT128_07905)	-	1514907..1515281 (-)	375	WP_011681547.1	membrane protein	-
STT128_RS07825 (STT128_07910)	pflA	1515493..1516293 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=449484 STT128_RS07795 WP_002951720.1 1510784..1511569(-) (codY) [Streptococcus thermophilus strain ST128]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=449484 STT128_RS07795 WP_002951720.1 1510784..1511569(-) (codY) [Streptococcus thermophilus strain ST128]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502