Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   STAVA116_RS01390 Genome accession   NZ_CP065498
Coordinates   256000..256899 (+) Length   299 a.a.
NCBI ID   WP_011225448.1    Uniprot ID   Q5M612
Organism   Streptococcus thermophilus strain AVA116     
Function   activate transcription of comX; activate transcription of comS (predicted from homology)   
Competence regulation

Genomic Context

Location: 251000..261899
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STAVA116_RS01370 (STAVA116_01360) trkA 252136..253485 (-) 1350 WP_011225444.1 Trk system potassium transporter TrkA -
  STAVA116_RS01375 (STAVA116_01365) - 253774..254283 (+) 510 WP_011680717.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
  STAVA116_RS01380 (STAVA116_01370) - 254594..255151 (+) 558 WP_002949523.1 ECF transporter S component -
  STAVA116_RS01385 (STAVA116_01375) - 255154..255804 (+) 651 WP_087009667.1 phosphatase PAP2 family protein -
  STAVA116_RS01390 (STAVA116_01380) comR 256000..256899 (+) 900 WP_011225448.1 helix-turn-helix domain-containing protein Regulator
  STAVA116_RS01395 - 257137..257568 (+) 432 Protein_234 cysteine peptidase family C39 domain-containing protein -
  STAVA116_RS01400 - 257598..258314 (+) 717 Protein_235 ABC transporter transmembrane domain-containing protein -
  STAVA116_RS01405 (STAVA116_01405) - 258600..259168 (+) 569 Protein_236 ATP-binding cassette domain-containing protein -
  STAVA116_RS01410 (STAVA116_01410) - 259276..259590 (+) 315 WP_087009669.1 DUF805 domain-containing protein -
  STAVA116_RS01415 - 259555..259842 (-) 288 WP_231906193.1 hypothetical protein -
  STAVA116_RS01420 - 259811..260158 (-) 348 WP_331711859.1 DUF4153 domain-containing protein -
  STAVA116_RS01425 - 260083..260979 (-) 897 WP_224103642.1 urease cluster protein -
  STAVA116_RS01430 (STAVA116_01420) - 261384..261899 (+) 516 WP_002949547.1 AmiS/UreI family transporter -

Sequence

Protein


Download         Length: 299 a.a.        Molecular weight: 35303.77 Da        Isoelectric Point: 5.1073

>NTDB_id=449322 STAVA116_RS01390 WP_011225448.1 256000..256899(+) (comR) [Streptococcus thermophilus strain AVA116]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide


Download         Length: 900 bp        

>NTDB_id=449322 STAVA116_RS01390 WP_011225448.1 256000..256899(+) (comR) [Streptococcus thermophilus strain AVA116]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterProScan.

ComR tetratricopeptide (ComR_TPR)

(75-292)

Helix-turn-helix (HTH_3)

(11-66)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5M612

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus thermophilus LMG 18311

100

100

1
  comR Streptococcus thermophilus LMD-9

99.331

100

0.993
  comR Streptococcus salivarius strain HSISS4

95.318

100

0.953
  comR Streptococcus salivarius SK126

94.649

100

0.946
  comR/comR1 Streptococcus sobrinus strain NIDR 6715-7

42.14

100

0.421
  comR/comR2 Streptococcus sobrinus strain NIDR 6715-7

42.14

100

0.421