Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexA   Type   Machinery gene
Locus tag   STCNRZ385_RS00370 Genome accession   NZ_CP065495
Coordinates   63036..65594 (+) Length   852 a.a.
NCBI ID   WP_014607836.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain CNRZ385     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 58036..70594
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STCNRZ385_RS00335 (STCNRZ385_00330) - 58867..59352 (+) 486 WP_071417453.1 NUDIX hydrolase -
  STCNRZ385_RS00340 (STCNRZ385_00335) - 59356..59547 (+) 192 WP_011681104.1 hypothetical protein -
  STCNRZ385_RS00345 (STCNRZ385_00340) - 59725..60174 (+) 450 WP_041827402.1 hypothetical protein -
  STCNRZ385_RS00350 (STCNRZ385_00345) - 60437..60630 (+) 194 Protein_48 hypothetical protein -
  STCNRZ385_RS00355 (STCNRZ385_00350) - 60742..61512 (+) 771 WP_014607834.1 type II toxin-antitoxin system PemK/MazF family toxin -
  STCNRZ385_RS00360 (STCNRZ385_00355) argR 62256..62684 (+) 429 WP_024704313.1 arginine repressor -
  STCNRZ385_RS00365 (STCNRZ385_00360) - 62684..63043 (+) 360 WP_011225277.1 YlbF family regulator -
  STCNRZ385_RS00370 (STCNRZ385_00365) hexA 63036..65594 (+) 2559 WP_014607836.1 DNA mismatch repair protein MutS Machinery gene
  STCNRZ385_RS09890 (STCNRZ385_00370) - 65628..66083 (-) 456 Protein_53 DUF3021 domain-containing protein -
  STCNRZ385_RS00385 (STCNRZ385_00375) - 66080..66471 (-) 392 Protein_54 LytTR family DNA-binding domain-containing protein -
  STCNRZ385_RS00390 (STCNRZ385_00380) - 66695..67000 (+) 306 WP_002949050.1 hypothetical protein -
  STCNRZ385_RS00395 (STCNRZ385_00385) hexB 67052..68995 (+) 1944 WP_014607839.1 DNA mismatch repair endonuclease MutL Machinery gene
  STCNRZ385_RS00400 (STCNRZ385_00390) - 69125..69346 (+) 222 WP_002949052.1 hypothetical protein -
  STCNRZ385_RS00405 (STCNRZ385_00395) ruvA 69498..70088 (+) 591 WP_011680603.1 Holliday junction branch migration protein RuvA Machinery gene

Sequence

Protein


Download         Length: 852 a.a.        Molecular weight: 95483.73 Da        Isoelectric Point: 4.7412

>NTDB_id=449102 STCNRZ385_RS00370 WP_014607836.1 63036..65594(+) (hexA) [Streptococcus thermophilus strain CNRZ385]
MAKEKISPGMQQYLDIKKNYPDAFLLFRMGDFYELFYDDAVKAAQILEISLTSRNKNADNPIPMAGVPYHSAQAYIDVLV
EMGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSANNFLVAIDKVGSRFGLSYMDVSTGEFFATELDDFSS
VCSEIQNLKAREVVVGYDLLETDEQVLVNQLNLLLSKETEGYDDVHLIGNSLTDLESSVASKLLQYVHRTQMRELSHLQK
AQHYEIKDYLQMSYATKSSLDLLENARTGKKHGSLFWLLDKTKTAMGMRLLRTWIDRPLVNQASIIERQNIIQVFLDNFF
ERSDLTESLKGVYDIERLASRVSFGKANPKDLIQLGHTLAQVPVIKAILESFNDDTLSGLLQELDALPELESLIRSAIDP
DAPATITEGGIIRDGFDETLDKYRKVMSEGTSWIADIEAKEREASGITTLKIDYNRKDGYYFHVTNSNLSLVPDHFFRKA
TLKNSERFGTAELAKIEGEMLEAREKSSTLEYDIFMRVREQVERYIDRLQSLAKAIATVDVLQSLAVTAETNHYVRPVFN
DEHRIAIDRGRHAVVEKVMGVQEYIPNTITFDSQTNIQLITGPNMSGKSTYMRQLALSVVMAQMGAYVPADSVDLPVFDA
IYTRIGAADDLISGQSTFMVEMMEANQAIKRATPNSLIIFDELGRGTATYDGMALAQSIIEFIHDKVGAKTMFATHYHEL
TALSNSLIHLVNVHVATLEKDGEVTFLHKIVDGPADKSYGIHVAKIAGLPTDLLNRADTILTQLEGETVVIQPQEKVSSQ
EKPAIETHVNEQISLFDDFTENPVLQELRDLDIYNMTPMQVMMAVADLKQKL

Nucleotide


Download         Length: 2559 bp        

>NTDB_id=449102 STCNRZ385_RS00370 WP_014607836.1 63036..65594(+) (hexA) [Streptococcus thermophilus strain CNRZ385]
ATGGCTAAGGAAAAGATATCTCCAGGAATGCAGCAGTATTTGGATATCAAGAAAAATTATCCAGATGCTTTTTTGCTGTT
TCGGATGGGGGATTTTTACGAATTATTTTACGATGATGCTGTTAAGGCTGCCCAGATTTTGGAAATTAGCCTAACTAGCC
GTAATAAGAATGCAGATAATCCCATTCCTATGGCAGGTGTGCCTTATCATTCAGCTCAAGCATACATTGATGTTTTGGTT
GAGATGGGCTACAAGGTAGCCATTGCTGAGCAGATGGAGGATCCTAAGCAGGCTGTCGGTGTGGTAAAGCGTGAGGTTGT
TCAGGTTATCACACCAGGTACAGTGGTTGACAGCTCTAAACCTGATAGTGCCAACAATTTCTTGGTGGCCATTGACAAGG
TTGGAAGTCGTTTTGGTCTTTCCTATATGGATGTGTCAACGGGTGAATTTTTTGCGACAGAGTTGGATGATTTTAGTTCA
GTTTGTAGTGAAATTCAGAACCTTAAGGCACGTGAAGTAGTGGTTGGATATGATCTACTTGAAACTGACGAACAAGTTTT
AGTGAACCAACTTAACCTACTTCTCTCCAAGGAAACAGAAGGTTACGATGATGTTCACTTGATTGGTAATAGCTTGACAG
ATTTGGAAAGCAGTGTGGCAAGTAAACTTCTCCAGTATGTTCATCGCACTCAGATGCGTGAGCTCAGTCATTTACAAAAA
GCTCAGCACTATGAGATAAAGGATTACTTGCAGATGTCCTATGCGACCAAGTCAAGCTTGGATTTACTGGAAAATGCTAG
AACGGGCAAGAAACACGGTTCTCTTTTCTGGCTCTTGGATAAAACCAAGACAGCCATGGGAATGCGTCTCTTGCGAACTT
GGATTGATCGTCCTTTAGTGAATCAAGCCAGCATCATAGAGCGTCAGAATATTATCCAAGTTTTCTTGGACAATTTCTTT
GAGCGTAGTGACTTGACCGAGAGTCTAAAAGGTGTTTACGATATTGAGCGTCTGGCCAGTCGTGTTTCCTTTGGCAAGGC
TAATCCTAAAGATTTAATTCAGCTAGGTCATACCTTAGCTCAGGTTCCGGTCATTAAGGCAATCTTGGAGTCCTTTAATG
ACGATACCTTGTCAGGTCTTTTACAAGAGTTAGATGCTTTGCCAGAATTAGAGAGTTTGATTCGTTCGGCTATTGATCCT
GATGCTCCAGCAACAATTACAGAAGGTGGTATTATTCGTGATGGTTTTGATGAGACCTTGGACAAGTATCGCAAAGTGAT
GAGCGAGGGGACGTCATGGATTGCGGATATCGAAGCAAAAGAACGCGAAGCGTCTGGTATTACAACACTAAAAATTGATT
ATAACCGTAAAGATGGTTATTACTTCCATGTGACCAACTCTAACCTTAGTTTGGTTCCTGACCATTTCTTCCGTAAGGCG
ACACTGAAAAATTCGGAGCGTTTTGGAACTGCTGAGTTGGCTAAGATTGAAGGTGAAATGCTAGAAGCACGTGAAAAATC
GTCAACCCTAGAGTATGATATTTTCATGCGTGTCCGTGAGCAGGTTGAACGCTATATCGACCGTTTGCAGTCTTTGGCTA
AGGCCATTGCAACAGTCGATGTGCTTCAGAGTTTGGCTGTTACAGCGGAGACAAATCATTATGTTCGTCCTGTTTTTAAT
GATGAGCATCGTATCGCTATTGATCGGGGCCGTCATGCGGTGGTTGAGAAGGTTATGGGCGTTCAGGAATACATTCCAAA
TACGATTACCTTTGACAGTCAGACCAATATTCAGCTCATCACAGGACCAAATATGAGTGGTAAATCTACCTATATGCGGC
AGTTAGCCTTGTCAGTAGTTATGGCTCAAATGGGGGCTTACGTACCAGCAGATAGTGTTGATTTACCTGTTTTTGACGCC
ATCTATACACGTATAGGTGCCGCAGATGACCTGATTTCAGGTCAGTCGACCTTCATGGTTGAGATGATGGAGGCTAATCA
GGCCATTAAGCGAGCGACACCTAATTCCTTGATTATTTTTGATGAGTTGGGGCGTGGGACAGCCACTTATGATGGTATGG
CTTTGGCCCAGTCTATTATTGAGTTTATTCATGACAAGGTTGGGGCTAAGACCATGTTTGCTACCCATTATCATGAGTTG
ACTGCGCTGTCAAACAGTTTGATACACCTTGTCAACGTCCATGTTGCGACACTTGAAAAGGATGGCGAAGTGACTTTCCT
CCACAAAATTGTCGATGGTCCAGCCGATAAATCGTATGGTATTCATGTAGCTAAAATTGCAGGTTTACCAACAGATTTAT
TGAACCGTGCTGACACCATATTGACACAATTAGAAGGAGAGACAGTTGTAATCCAACCTCAGGAAAAGGTATCGTCTCAA
GAAAAGCCTGCCATTGAAACGCATGTCAACGAGCAAATCTCTCTCTTTGATGACTTTACTGAAAATCCGGTTCTTCAAGA
GTTGCGTGATTTGGACATTTACAACATGACACCGATGCAAGTCATGATGGCTGTAGCAGATTTAAAACAGAAACTATAA

Domains

Predicted by InterProScan.

MutS domain V (MutS_V)

(599-785)

MutS domain I (MutS_I)

(8-118)

MutS family domain IV (MutS_IV)

(415-505)

MutS domain III (MutS_III)

(256-546)

MutS domain II (MutS_II)

(126-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexA Streptococcus pneumoniae R6

74.061

100

0.741
  mutS Pseudomonas stutzeri strain ATCC 17587

35.788

100

0.365