Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   HQ616_RS02900 Genome accession   NZ_CP053891
Coordinates   510380..512641 (-) Length   753 a.a.
NCBI ID   WP_000882549.1    Uniprot ID   A0A0E1EFR4
Organism   Streptococcus agalactiae strain GBS20     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 505380..517641
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HQ616_RS02880 (HQ616_02875) - 505410..506180 (+) 771 WP_001131467.1 DivIVA domain-containing protein -
  HQ616_RS02885 (HQ616_02880) ileS 506464..509256 (+) 2793 WP_000768155.1 isoleucine--tRNA ligase -
  HQ616_RS02890 (HQ616_02885) - 509373..509675 (-) 303 WP_001237035.1 DUF1827 family protein -
  HQ616_RS02895 (HQ616_02890) - 509739..510194 (-) 456 WP_000184292.1 NUDIX hydrolase -
  HQ616_RS02900 (HQ616_02895) clpE 510380..512641 (-) 2262 WP_000882549.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  HQ616_RS02905 (HQ616_02900) - 512939..513169 (+) 231 WP_000443582.1 DUF1797 family protein -
  HQ616_RS02910 (HQ616_02905) - 513311..514003 (+) 693 WP_001011647.1 amino acid ABC transporter permease -
  HQ616_RS02915 (HQ616_02910) - 513996..514730 (+) 735 WP_000230131.1 amino acid ABC transporter ATP-binding protein -
  HQ616_RS02920 (HQ616_02915) - 515017..516711 (+) 1695 WP_001106845.1 phospho-sugar mutase -

Sequence

Protein


Download         Length: 753 a.a.        Molecular weight: 83766.92 Da        Isoelectric Point: 5.2771

>NTDB_id=448741 HQ616_RS02900 WP_000882549.1 510380..512641(-) (clpE) [Streptococcus agalactiae strain GBS20]
MLCQNCKLNESTIHLYTNVNGKQKQVDLCQNCYQIIKTDPNNPLFSGLNHVSHAPGGINPFFDDFFGDLNNFRAFNGQDL
PNTPPTQSGGNRGGGNGNGRNNNRNQTATPSQAKGILEEFGINVTEIARHGDIDPVIGRDSEIIRVIEILNRRTKNNPVL
IGEPGVGKTAVVEGLAQKIVDGNVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVG
AGTAGEGSMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQKKYEDYHHVKY
NNDAIEAAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDQRLIEAENLKAQATREEDYERAAYFRDQIAK
YKEMQQQKVDDQDTPIITEKTIEHIIEEKTNIPVGDLKEKEQSQLINLADDLKQHVIGQDDAVVKIAKAIRRNRVGLGSP
NRPIGSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLI
LLDEIEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGSGKTEASVGFGASREGRTNSVLGQLGNFFSPEF
MNRFDGIIEFKALDKENLLNIVDIMLSDVNARLAINGIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQEHIEDAITDYY
LENPSEKELRAIMTSNGNIIIKSSKKTEESTKG

Nucleotide


Download         Length: 2262 bp        

>NTDB_id=448741 HQ616_RS02900 WP_000882549.1 510380..512641(-) (clpE) [Streptococcus agalactiae strain GBS20]
ATGCTCTGTCAAAACTGCAAACTAAACGAATCAACTATTCATTTGTATACAAATGTTAATGGAAAACAAAAGCAAGTTGA
TCTTTGTCAAAATTGCTACCAAATTATTAAAACTGACCCTAATAATCCACTTTTTTCAGGTTTAAATCATGTTTCACATG
CGCCTGGTGGCATCAATCCTTTCTTTGATGATTTCTTTGGAGATTTAAATAATTTCAGAGCCTTTAATGGCCAAGATTTA
CCAAACACTCCTCCTACACAATCAGGAGGAAACCGAGGTGGAGGAAACGGTAATGGACGAAATAATAATCGCAACCAAAC
TGCAACTCCTTCTCAAGCCAAAGGGATTCTAGAAGAATTTGGTATCAATGTCACTGAAATAGCCCGCCATGGTGATATTG
ACCCTGTTATTGGACGTGACTCAGAAATTATTCGTGTTATCGAAATCCTTAATCGTCGTACAAAAAATAATCCTGTACTT
ATTGGCGAACCCGGCGTTGGGAAAACTGCCGTTGTTGAAGGACTTGCTCAGAAAATTGTTGATGGTAATGTGCCTCATAA
ACTTCAAGGCAAACAAGTTATTCGTTTGGATGTTGTGAGTCTAGTACAAGGAACGGGCATTCGTGGTCAATTTGAAGAAC
GCATGCAAAAGTTGATGGAAGAAATTCGTCAACGTCAAGATGTTATTCTATTCATAGATGAAATTCACGAAATAGTTGGA
GCTGGTACAGCTGGCGAAGGTAGTATGGATGCAGGTAATATTTTAAAACCTGCCCTTGCACGTGGAGAATTACAACTAGT
AGGTGCTACTACTCTCAATGAATATCGTATTATCGAAAAGGACGCTGCCTTAGAACGCCGTATGCAACCTGTAAAAGTCG
ATGAGCCTTCTGTTGAAGAAACCATTACTATTTTGAAAGGTATCCAAAAAAAATACGAAGATTATCATCATGTAAAATAT
AATAATGATGCCATAGAAGCAGCTGCAGTACTATCTAATCGTTATATCCAGGACCGCTTTTTACCTGATAAAGCAATAGA
CTTATTAGATGAAGCTGGTTCTAAAATGAACCTAACACTAAATTTTGTTGATCCAAAAGAAATTGATCAACGTCTCATTG
AAGCAGAAAATTTAAAAGCGCAAGCGACTCGTGAAGAAGATTACGAACGTGCAGCTTACTTCCGTGACCAGATTGCAAAA
TATAAAGAAATGCAACAACAAAAGGTCGACGATCAAGATACACCTATTATTACCGAAAAAACAATTGAGCACATCATTGA
AGAAAAAACGAATATCCCTGTTGGTGATTTAAAAGAAAAAGAACAATCTCAATTAATTAATCTCGCAGATGACTTGAAAC
AACATGTGATCGGCCAGGATGACGCTGTCGTTAAGATTGCAAAAGCTATTCGTCGTAATCGAGTTGGTCTTGGTAGCCCA
AACCGTCCTATTGGTTCCTTTTTATTTGTAGGACCAACCGGCGTTGGTAAAACTGAACTTTCTAAACAACTAGCAATTGA
GCTCTTTGGTTCAGCTGATAGTATGATTCGTTTTGATATGTCAGAGTACATGGAAAAGCATGCTGTTGCTAAATTAGTCG
GAGCGCCTCCAGGATACGTGGGATACGAGGAAGCTGGACAATTAACTGAAAAGGTTCGTCGAAATCCTTACTCGCTCATC
CTTCTAGATGAAATTGAAAAAGCTCATCCTGATGTCATGCATATGTTCTTGCAGGTCCTTGATGACGGTCGATTAACAGA
TGGACAAGGAAGAACTGTTAGTTTTAAAGATACCATTATCATCATGACCTCAAATGCTGGTTCTGGTAAAACTGAAGCAA
GCGTTGGCTTTGGTGCCTCACGAGAAGGTAGAACGAATTCCGTACTAGGTCAACTAGGTAACTTCTTCAGCCCTGAATTT
ATGAACCGCTTTGACGGTATTATTGAATTCAAGGCTTTAGATAAAGAGAATCTCCTCAATATCGTTGATATTATGTTATC
TGACGTTAATGCACGTCTCGCCATCAATGGTATTCATCTAGATGTCACTGATAAAGTGAAAGAAAAATTGGTTGATTTAG
GTTACGATCCCAAAATGGGAGCACGTCCATTACGTCGTACCATTCAAGAACATATTGAAGATGCTATCACAGATTACTAT
CTTGAGAATCCAAGCGAAAAAGAACTTCGTGCTATTATGACTAGCAATGGAAATATCATAATAAAATCTTCTAAAAAAAC
TGAAGAAAGTACAAAAGGTTGA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(482-645)

ATPase family associated with various cellular activities (AAA) (AAA)

(159-276)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(653-727)

AAA lid domain (AAA_lid_9)

(297-394)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E1EFR4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

85.676

100

0.858
  clpE Streptococcus pneumoniae Rx1

85.714

99.469

0.853
  clpE Streptococcus pneumoniae D39

85.714

99.469

0.853
  clpE Streptococcus pneumoniae R6

85.714

99.469

0.853
  clpE Streptococcus pneumoniae TIGR4

85.581

99.469

0.851
  clpC Lactococcus lactis subsp. cremoris KW2

74.867

99.867

0.748
  clpC Bacillus subtilis subsp. subtilis str. 168

51.327

90.04

0.462
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.528

83.267

0.396
  clpC Streptococcus pneumoniae Rx1

47.003

84.197

0.396
  clpC Streptococcus pneumoniae D39

47.003

84.197

0.396
  clpC Streptococcus pneumoniae TIGR4

46.845

84.197

0.394
  clpC Streptococcus thermophilus LMD-9

46.276

83.798

0.388
  clpC Streptococcus mutans UA159

46.87

82.736

0.388
  clpC Streptococcus thermophilus LMG 18311

45.959

83.798

0.385