Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGE   Type   Machinery gene
Locus tag   ST4078_RS08830 Genome accession   NZ_CP065477
Coordinates   1693426..1693719 (-) Length   97 a.a.
NCBI ID   WP_011226625.1    Uniprot ID   Q5M2G2
Organism   Streptococcus thermophilus strain 4078     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1688426..1698719
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST4078_RS08790 (ST4078_08735) - 1688828..1689271 (-) 444 WP_011681680.1 hypothetical protein -
  ST4078_RS08795 - 1689345..1689683 (-) 339 WP_224103197.1 CPBP family intramembrane glutamic endopeptidase -
  ST4078_RS08800 - 1689727..1690002 (-) 276 WP_011681681.1 hypothetical protein -
  ST4078_RS08805 (ST4078_08745) - 1690014..1690211 (-) 198 WP_011681682.1 helix-turn-helix transcriptional regulator -
  ST4078_RS08810 (ST4078_08750) - 1690460..1691653 (-) 1194 WP_014608740.1 acetate kinase -
  ST4078_RS08815 (ST4078_08755) comGH 1691709..1692665 (-) 957 WP_014608741.1 class I SAM-dependent methyltransferase Machinery gene
  ST4078_RS08820 (ST4078_08760) comGG 1692710..1693027 (-) 318 WP_002952035.1 competence type IV pilus minor pilin ComGG Machinery gene
  ST4078_RS08825 (ST4078_08765) comGF 1693005..1693442 (-) 438 WP_014608742.1 competence type IV pilus minor pilin ComGF Machinery gene
  ST4078_RS08830 (ST4078_08770) comGE 1693426..1693719 (-) 294 WP_011226625.1 competence type IV pilus minor pilin ComGE Machinery gene
  ST4078_RS08835 (ST4078_08775) comGD 1693691..1694119 (-) 429 WP_011226626.1 competence type IV pilus minor pilin ComGD Machinery gene
  ST4078_RS08840 (ST4078_08780) comGC 1694079..1694405 (-) 327 WP_002946126.1 competence type IV pilus major pilin ComGC Machinery gene
  ST4078_RS08845 (ST4078_08785) comGB 1694402..1695502 (-) 1101 WP_116920398.1 competence type IV pilus assembly protein ComGB Machinery gene
  ST4078_RS08850 (ST4078_08790) comGA/cglA/cilD 1695384..1696325 (-) 942 WP_014608745.1 competence type IV pilus ATPase ComGA Machinery gene
  ST4078_RS08855 (ST4078_08795) - 1696406..1696768 (-) 363 WP_014608746.1 DUF1033 family protein -

Sequence

Protein


Download         Length: 97 a.a.        Molecular weight: 10844.74 Da        Isoelectric Point: 10.4561

>NTDB_id=447425 ST4078_RS08830 WP_011226625.1 1693426..1693719(-) (comGE) [Streptococcus thermophilus strain 4078]
MVNIKRRSLRGYILIESLVAMAVLVLVSSLILEQINTNRRLMADNLHQQEVLSVATMAVQTKQDQLTLNGIAVTVKRSQQ
GITVYESGKEIIHVSKQ

Nucleotide


Download         Length: 294 bp        

>NTDB_id=447425 ST4078_RS08830 WP_011226625.1 1693426..1693719(-) (comGE) [Streptococcus thermophilus strain 4078]
GTGGTAAATATAAAAAGACGATCTCTTAGAGGTTATATTCTTATTGAAAGTCTGGTAGCTATGGCTGTTTTAGTACTTGT
CAGCAGTCTGATATTGGAACAAATTAATACCAACCGCAGACTAATGGCTGATAATCTCCATCAACAAGAGGTCTTGAGTG
TGGCAACAATGGCAGTTCAGACCAAGCAAGACCAGTTAACGCTGAATGGCATAGCGGTGACAGTTAAACGTAGCCAGCAA
GGTATCACGGTTTATGAATCGGGAAAGGAGATTATTCATGTATCTAAGCAGTAA

Domains

Predicted by InterProScan.

Type II secretory pathway pseudopilin (ComGE)

(13-94)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5M2G2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGE Streptococcus mutans UA140

43.299

100

0.433
  comGE Streptococcus mutans UA159

43.299

100

0.433
  comGE Lactococcus lactis subsp. cremoris KW2

36.082

100

0.361